Zolecon - cream Econazole Nitrate 1% topical - 1% 1 10gm tube(s) / 10gm tube Ad-din Pharmaceuticals Ltd. Indication: Tinea pedis, Tinea cruris, Tinea corporis, Jock itch, Athlet's foot, Pityriasis versicolor, Cutaneous candidiasis, Onychomycoses. Adult Dose: Topical/Cutaneous Nail fungal infections Adult: As 1% cream or lotion: Apply once daily under occlusive dressing. For tinea pedis: As 1% cream or foam: Apply once daily for 4 wk. Tinea cruris; Tinea versicolor; Tinea corporis Adult: As 1% cream: Apply once daily for 2 wk. Cutaneous candidiasis Adult: As 1% cream: Apply bid (morning and evening) for 2 wk. Child Dose: <3 months: Safety and efficacy not established Tinea pedis, cruris, corporis, versicolor: Apply cream to affected area(s) qDay Cutaneous candidiasis: Apply cream to affected area(s) BID Contraindication: Hypersensitivity. Mode of Action: Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism. Precaution: Avoid contact with eyes and mucous membranes. Pregnancy. Lactation: excretion in milk unknown; use with caution Side Effect: 1-10% Erythema (3%) Frequency Not Defined Burning and stinging sensations, Pruritus Pregnancy Category Note: Pregnancy There are no available data on therapy use in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. In animal reproduction studies, econazole nitrate did not cause malformation in mice, rabbits and/or rats at oral doses 80 or 40 times the human dermal dose Animal data Econazole nitrate did not cause malformation in mice, rabbits and/or rats; fetotoxic or embryotoxic effects were observed in oral fertility studies in rats receiving 10 to 40 times the human dermal dose; similar effects were observed in embryofetal and pre- and postnatal developmental studies... Interaction: May enhance anticoagulant effect of warfarin or acenocoumarol.