Volant 75 - capsule Pregabalin - 75mg 10 Capsule(s) / Strip C2C Pharma Introduction: Volant 75 is a medicine used to relieve pain caused by nerve damage (neuropathic pain) due to diabetes, shingles (herpes zoster infection), spinal cord injury, or other conditions. It is also used to treat widespread muscle pain and stiffness in people with fibromyalgia. Volant 75 belongs to the anti-epileptic group of medicines and can be used to treat certain types of seizures (fits) in combination with other medicines. It may also be prescribed to treat the symptoms of excessive anxiety in generalized anxiety disorder if other medicines are not suitable. You can take Volant 75 with or without food, but... Uses of Volant 75: Neuropathic painEpilepsy/SeizuresFibromyalgia Side effects of Volant 75: Blurred visionDifficulty in paying attentionDizzinessDryness in mouthEdema (swelling)SleepinessWeight gain How to use Volant 75: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Volant 75 may be taken with or without food, but it is better to take it at a fixed time. How Volant 75 works: Volant 75 is an antiepileptic medication. When given for epilepsy, it is believed to work by reducing the abnormal electrical activity in the brain, thus preventing seizures. It is also used to treat nerve pain where it blocks pain by interfering with pain signals travelling through the damaged nerves and the brain. For treatment of anxiety, it is believed to work by stopping the release of certain chemical messengers (neurotransmitters) that make you feel anxious. What if you forget to take Volant 75?: If you miss a dose of Volant 75, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Anxiety, Fibromyalgia, Post herpetic Neuralgia, Partial seizures, Pain from diabetic neuropathy, Neuropathic pain associated with spinal cord injury Administration: May be taken with or without food. Adult Dose: Oral Neuropathic pain, Postherpetic Neuralgia Adult: Initially, 150 mg/day, may increase to 300 mg/day after 3-7 days. Max: 600 mg/day after a 7-day interval. All doses to be given in 2 or 3 divided doses. Diabetic Peripheral Neuropathic Pain Initial: 50 mg PO q8hr Maintenance: May increase to 100 mg PO q8hr within 1 week, as needed; not to exceed 300 mg/day Adjunct in partial seizures Adult: Initially, 150 mg/day, may increase to 300 mg/day after a wk. Max: 600 mg/day. All doses to be given in 2 or 3 divided doses. Fibromyalgia Adult: Initially, 150 mg/day, may increase to... Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Haemodialysis: 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30 to <60 75 mg/day. Max: 300 mg/day. All doses to be given in 2 or 3 divided doses. 15 to <30 Initially, 25-50 mg/day. Max: 150 mg/day. All doses to be given as a single dose or in 2 divided doses. <15 Initially, 25 mg/day. Max: 75 mg/day. All doses to be given as a single dose. Contraindication: Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities. Mode of Action: Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, calcitonin gene-related peptide and substance P. Precaution: Abrupt or rapid discontinuation of Pregabalin may produce some symptoms including insomnia, nausea, headache and diarrhoea. So Pregabalin should be tapered gradually over a minimum of 1 week rather than discontinued abruptly. Pregabalin treatment may associate with creatine kinase elevations. It should be discontinued if myopathy is diagnosed or suspected or if markedly elevated creatine kinase levels occur. Discontinue treatment if patients develop severe angioedema. Regular vision check is recommended. May decrease platelet count and prolong PR interval. Patient w/ history of angioedema episodes, severe CV disease, renal impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive, operate... Side Effect: >10% Dizziness (8-45%),Somnolence (4-36%),Peripheral edema (16%),Ataxia (1-20%),Fatigue (5-11%),Xerostomia (1-15%),Weight gain (16%),Tremor (11%),Blurred vision (1-12%),Diplopia (12%) 1-10% Asthenia (5%),Edema (8%),Facial edema (1%),Incoordination (2%),Vomiting (1-3%),Balance disorder (2-9%),Myoclonus (4%),Nasopharyngitis pain (1-3%),Flu-like syndrome (1-2%) <1% Addiction,Anemia,Diarrhea,Gynecomastia and breast enlargement,Epididymitis,Esophagitis,Dysmenorrhea,Dystonia,Heart failure,Hirsutism,Uveitis <0.1% Neutropenia, first degree heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis, suicidal thoughts or behavior Interaction: May potentiate the effects of lorazepam. Additive CNS depressant effects w/ opiates and benzodiazepines. May increase risk of angioedema w/ ACE inhibitors. May increase risk of wt gain and peripheral oedema w/ thiazolidinediones.