Cyclid - Injection Procyclidine Hydrochloride - 10mg/2ml 1 Injection(s) / Injection Incepta Pharmaceuticals Ltd. Introduction: Cyclid is a prescription medicine used in the treatment of Parkinson's disease and drug induced abnormal movements. It helps by improving muscle control and reducing the stiffness of the muscle, so that they can move easily. Cyclid should be taken with food as it reduces the side effects with this medicine. It should be taken at the same time each day, this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember.... Uses of Cyclid: Parkinson's disease Side effects of Cyclid: Dryness in mouthNauseaVomitingConstipationBlurred visionDizzinessLightheadednessDilatation of pupilUpper abdominal painUrinary retention How to use Cyclid: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cyclid is to be taken with food. How Cyclid works: Cyclid is a muscle relaxing medication. It works by decreasing the activity of excess acetylcholine in the brain. This improves muscle control and reduces stiffness. It helps patients with Parkinson's disease by improving muscle control and reducing stiffness so that they can move more naturally. It is also used to treat movement disorder (restlessness, involuntary movements or muscle spasm ) which can be caused by certain drugs. Indication: Parkinsonism, Drug-induced extrapyramidal syndrome Adult Dose: Oral Parkinsonism and drug-induced extrapyramidal syndrome Adult: As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 days if required. Maintenance: 10-30 mg/day in 3-4 divided doses. Up to 60 mg daily may be required in some cases. Parenteral Parkinsonism and drug-induced extrapyramidal syndrome Adult: Emergency cases: IV admin: 5-10 mg, higher doses may be needed; IM admin: 5-10 mg as a single dose, may repeat after 20 minutes if needed, to a max of 20 mg daily. Elderly: Lower doses are required. Child Dose: Oral Dystonia in children Child: 7-12 yr: 1.25 mg tid; 12-18 yr: 2.5 mg tid. For emergency cases, a single dose may be given via IM or IV inj: <2 yr: 0.5-2 mg; 2-10 yr: 2-5 mg and 10-18 yr: 5-10 mg. Contraindication: Urinary outflow obstruction, prostatic hyperthrophy, narrow-angle glaucoma, paralytic ileus and pyloric stenosis. Mode of Action: Procyclidine is a tertiary amine antimuscarinic which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits direct antispasmodic effect on smooth muscle. Precaution: Patient w/ mental disorders, CV disease (e.g. tachycardia, cardiac arrhythmias, hypertention, hypotension). Hepatic and renal impairment. Avoid abrupt withdrawal. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause blurred vision, dizziness, confusion or disorientation, if affected, do not drive or operate machinery. Monitoring Parameters Monitor symptoms of extrapyramydal syndrome or Parkinson's disease, pulse, anticholinergic effects (e.g. CNS, bowel and bladder function). Side Effect: Dry mouth, mydriasis, blurred vision, lightheadedness, giddiness, disorientation, GI effects (e.g. nausea, vomiting, epigastric distress, constipation), allergic reaction (e.g. rash), muscular weakness; vertigo, confusion, hallucinations at high doses; tremor, acute suppurative parotitis. Interaction: Increased plasma concentrations w/ paroxetine. Enhanced anticholinergic action w/ MAOIs and other anticholinergic drugs. Reduced therapeutic effect w/ cholinergic drugs. May antagonise the effect of parasympathomimetic agents. May reduce the absorption and therapeutic effect of sublingual or buccal nitrate tab. May reduce the efficacy of levodopa. May antagonise the GI effects of cisapride, domperidone and metoclopramide. May potentiate the vagolytic effects of quinidine. May reduce the absorption of ketoconazole.