Zoladex LA 10.8 - Injection Goserelin - 10.8mg 1 10.8mg pre-filled syringe(s) / 10.8mg pre-filled syringe MGH Healthcare Limited Introduction: Zoladex LA 10.8 is used for the treatment of prostate cancer in men and for breast cancer, endometriosis and uterine fibroids in women. In combination with some other medicine, it is used in the treatment of female infertility. Zoladex LA 10.8 is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in... Uses of Zoladex LA 10.8: Prostate cancerBreast cancerEndometriosisUterine fibroidsFemale infertility Side effects of Zoladex LA 10.8: Increased sweatingDecreased libido How to use Zoladex LA 10.8: Your doctor or nurse will give you this medicine. Kindly do not self administer. How Zoladex LA 10.8 works: Zoladex LA 10.8 is a synthetic hormone. In men, it works by reducing the level of testosterone (male hormone) which causes regression of prostate tumor and improves symptoms. In women, it suppresses the level of estradiol (female hormone) which helps treat advanced breast cancer, endometriosis and uterine fibroids. It also reduces the thickness of the endometrium, which is the uterus lining, prior to surgery. Indication: Palliative treatment of prostatic carcinoma, Pituitary desensitisation before ovulation induction with gonadotrophins, Breast Cancer, Endometriosis Adult Dose: Subcutaneous Palliative treatment of prostatic carcinoma Adult: 3.6 mg injected into the anterior abdominal wall every 28 days or 10.8 mg every 12 wk. An anti-androgen is given several days before beginning of the treatment and continued for at least 3 wk to prevent disease flare. Pituitary desensitisation before ovulation induction with gonadotrophins Adult: 3.6 mg as a depot inj. Monitor serum-oestradiol concentrations until they decline to levels similar to those in the early follicular phase which takes about 7-21 days. Contraindication: Hypersensitivity; pregnancy, lactation. Mode of Action: Goserelin is a potent inhibitor of pituitary gonadotrophin secretion. Initially, it causes an increase in the serum levels of FSH and LH but chronic admin will lead to sustained suppression of the pituitary gonadotrophin release causing regression of the sex organs. Precaution: Urinary tract obstruction or spinal cord compression (when used for prostate cancer); decreased bone density in women. Contraceptive measures should be taken to protect against pregnancy. Monitor men at risk from tumour flare during the 1st mth of therapy. Safety and efficacy on the usage of the 10.8 mg implant in women is not established. Lactation: excretion in milk unknown; not recommended Side Effect: >10% Flushing (46-96%),Vaginitis (5-75%),Hot flashes (62%),Reduced libido (47-61%),Mood swings (60%),Depression (women 54%),Sweating (16-45%),Acne (42%),Diarrhea (40%),Breast atrophy (33%),Headache (women 32-75%),Seborrhea (26%),Tumor flare (23%),Sexual dysfunction (21%),Peripheral edema (21%),Erectile dysfunction (18%),Pain (8-17%),UTI (13%) 1-10% Nausea (9%),Lethargy (8%),Rash (6%),Chronic obstructive pulmonary disease (5%),Congestive heart failure(5%),Cerebrovascular accident (1-5%),Renal impairment (1-5%),Headache (men 1-5%),Depression (men 1-5%),Immune hypersensitivity reaction (>1%) Frequency Not Defined Asthenia,Hypercalcemia,Cystitis,Dysmenorrhea,Hirsutism,Dyspareunia,Breast changes,Implant site reactions,Bone pain,Spinal cord compression (rare)