Z-Lidocaine jelly 30gm - Gel Lidocaine (lignocaine) Hydrochloride 2%, 10% - 2% 1 30gm tube(s) / 30gm tube Ziska Pharmaceuticals Ltd. Introduction: Z-Lidocaine jelly 30gm is a local anesthetic used to temporarily numb certain areas of the body. It is used as an anesthetic lubricant to insert of instruments in the human body for medical procedures (e.g., catheters). It is also used for the treatment of symptoms of painful inflammation of the urethra and bladder. The most common side effects of this medicine include redness, rash, burning and itching on the area of application. These are usually mild and short-lived. Consult your doctor if any of the side effects persist or worry you. Before using it, tell your doctor if you have... Uses of Z-Lidocaine jelly 30gm: Local anesthesia (Numb tissues in a specific area) Side effects of Z-Lidocaine jelly 30gm: Allergic reactionApplication site reactions (burning, irritation, itching and redness) How to use Z-Lidocaine jelly 30gm: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area. How Z-Lidocaine jelly 30gm works: Z-Lidocaine jelly 30gm is a local anesthetic. It works on the skin by blocking pain signals from the nerves to brain. This numbs the area and decreases pain sensation. Indication: Hemorrhoids, Itching, Perianal pain and itching, Postherpetic Neuralgia, Surface anaesthesia, Burning and pain and skin inflammations, Anorectal disorders, Anesthetic Lubricant for Intubation Adult Dose: Topical as Gel/Jelly Mouth/Throat Surface anaesthesia Adult: As 2% soln (Gel): For pain: 300 mg rinsed and ejected for mouth and throat pain; or gargled and swallowed if necessary for pharyngeal pain. Not to be used more frequently than every 3 hr. Max (topical oral soln): 2.4 g/day. Anesthetic Lubricant for Intubation Indicated as an anesthetic lubricant for oral or nasal endotracheal intubation Gel (2%): Apply moderate amount to external surface of endotracheal tube shortly before use Not to exceed 600 mg/12 hr Urethral Surface Anesthesia When using Xylocaine 2% Jelly 30 mL tubes for urologic procedures, sterilize the plastic... Child Dose: Topical as Gel/Jelly Anesthetic Lubricant for Intubation Indicated as an anesthetic lubricant for oral or nasal endotracheal intubation Jelly (2%): Apply moderate amount to external surface of endotracheal tube shortly before use Children aged 2 years: Apply topically to affected area TID/QID Rectal as gel/jelly Haemorrhoids; Perianal pain and itching Child: >12 yr Apply topically or using applicator insert rectally, up to 6 times daily. Contraindication: Hypovolaemia; heart block or other conduction disturbances. Mode of Action: Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced. Precaution: Hepatic or renal impairment; CHF and following cardiac surgery; bradycardia; respiratory depression; porphyria; elderly or debilitated patients; pregnancy. Lactation: Distributed in human breast milk; caution advised Side Effect: Application site reactions Abnormal sensation,Pallor or blanching when the application time is very prolonged (>2 hr),Alterations in temperature sensations,Edema,Itching,Rash Systemic reactions Unlikely due to the small dose absorbed; may occur with repeated doses or application to large surface area CNS excitation and/or depression Light-headedness, nervousness, apprehension, euphoria, confusion Dizziness,Drowsiness,Tinnitus,Blurred or double vision,Vomiting,Sensations of heat, cold or numbness,Twitching, tremors, convulsions.Unconsciousness, respiratory depression, and arrest.Cardiovascular manifestations (eg, bradycardia, hypotension, and cardiovascular collapse leading to arrest) Potentially Fatal: Hypotension and bradycardia leading to cardiac arrest; anaphylaxis. Interaction: May increase serum levels w/ cimetidine and propranolol. Increased risk of cardiac depression w/ beta-blockers and other antiarrhythmics. Additive cardiac effects w/ IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased w/ long-term use of phenytoin and other enzyme-inducers.