Vesotan - Tablet Candesartan Cilexetil - 8mg 1 Tablet(s) / Tablet Rangs Pharmaceuticals Ltd. Introduction: Vesotan is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Vesotan can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most... Uses of Vesotan: Hypertension (high blood pressure)Heart failurePrevention of heart attack and stroke Side effects of Vesotan: DizzinessBack painUpper respiratory tract infectionSore throatNasal congestion (stuffy nose) How to use Vesotan: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vesotan may be taken with or without food, but it is better to take it at a fixed time. How Vesotan works: Vesotan is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently. What if you forget to take Vesotan?: If you miss a dose of Vesotan, skip it and continue with your normal schedule. Do not double the dose. Indication: Hypertension, Congestive heart failure Administration: May be taken with or without food. Adult Dose: Oral Hypertension Adult: Initially, 8 mg once daily adjusted according to response. Maintenance: 8 mg once daily. Max: 32 mg/day as single or in 2 divided doses. Patients w/ intravascular volume depletion: Initially, 4 mg once daily. Heart failure Adult: Initially, 4 mg once daily, may be doubled at intervals of not <2 wk. Max: 32 mg once daily. Hepatic impairment: Mild to moderate: Initially, 4 mg once daily. Severe: Contraindicated. Child Dose: Oral Hypertension Child: 1 to 6 yr 50 kg: 8-16 mg/day, adjusted according response to 4-32 mg/day. All doses may be given as single or in 2 divided doses. Renal Dose: Renal Impairment No dose adjustment necessary for patients with mild renal impairment Initiate thearpy at lower dose if moderate renal impairment Contraindication: Hypersensitivity. Pregnancy (2nd and 3rd trimester) and lactation. Mode of Action: Candesartan inhibits the binding of angiotensin II to AT1 receptors in many tissues (e.g. vascular smooth muscles, adrenal gland) which leads to vasoconstriction blockade and aldosterone release. Precaution: Volume or sodium depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients with a history of angioedema, urticaria. Monitor serum potassium levels especially in elderly and renally impaired patients. Hypotension may occur during major surgery and anaesthesia due to suppression of the renin-angiotensin system. Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death Lactation: Not known if excreted in... Side Effect: Dizziness, headache, vertigo, back pain, upper resp tract infections, pharyngitis, rhinitis, hypotension, hyperkalaemia, increased serum creatinine. Pregnancy Category Note: Pregnancy Category: D Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death Lactation: Not known if excreted in breast milk; not recommended Interaction: NSAIDs may reduce antihypertensive effect and result in deterioration of renal function including possible acute renal failure. May increase serum lithium concentration. K-sparing diuretics, K supplements or salt substitutes containing K may increase risk of hyperkalaemia. Potentially Fatal: Coadministration w/ aliskiren in diabetic patients may increase risk of renal impairment, hypotension and hyperkalaemia.