Vencuron - Injection Vecuronium Bromide - 10mg/ml 1 10mg vial(s) / 10mg vial Techno Drugs LTD. Introduction: Vencuron belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It is also used to facilitate emergency airway management in patients in intensive care. Vencuron is administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions such as pain, redness, and swelling. Long-term use of this medicine may... Uses of Vencuron: Skeletal mucle relaxation during surgery Side effects of Vencuron: Skin rashIncreased saliva productionInjection site reactions (pain, swelling, redness)High blood pressure How to use Vencuron: Your doctor or nurse will give you this medicine. Kindly do not self administer. How Vencuron works: Vencuron relaxes the muscles by blocking the impulses from the nerves. Indication: General anaesthesia, Skeletal muscle relaxation Adult Dose: Intravenous Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care Adult: Initially, 80-100 mcg/kg by inj. Maintenance: 20-30 mcg/kg by inj or as continuous infusion at 0.8-1.4 mcg/kg/min. Surgical procedures after intubation w/ suxamethonium: 30-50 mcg/kg. Caesarean section: <100 mcg/kg. Surgery under halothane and neurolept anaesth: Initially, 150-300 mcg/kg. Child Dose: Intravenous Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care Child: 4 month: 80-100 mcg/kg by inj. Maintenance: 20-30 mcg/kg by inj or as continuous infusion at 0.8-1.4 mcg/kg/min. Neonatal surgery: <100 mcg/kg. Contraindication: Hypersensitivity to vecuronium or bromide. Mode of Action: Vecuronium bromide inhibits depolarisation by blocking acetylcholine from binding to receptors on motor endplate. Precaution: Patient w/ CV disease, oedema, neuromuscular disease, previous poliomyelitis, burn injury, severe electrolyte disturbances, altered blood pH, dehydration; obese patient. Hepatic and renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor BP, heart rate; peripheral nerve stimulation. Side Effect: Skeletal muscle weakness or paralysis, resp insufficiency or apnoea, bronchospasm, hypotension, tachycardia, acute urticaria, erythema, minimal induration, redness, itching, CV effects (e.g. changes in heart rate, cardiac index), myopathy. Potentially Fatal: Anaphylaxis. Interaction: Increases neuromuscular blockade with volatile anaesthetic agents (halothane, ether, enflurane, isoflurane, methoxyflurane, propofol and cyclopropane), fentanyl, other non-depolarising muscle relaxants, prior admin of succinylcholine, tetracyclines, polymyxins, diuretics, thiamine, MAOIs, bacitracin, colistin, sodium colistimethate, acylaminopenicillins, aminoglycoside antibiotics, high dose metronidazole, protamine, beta-adrenergic blocking agents, calcium antagonists e.g. verapamil, and Mg. Decreased neuromuscular blockade with anticholinesterases, prior chronic admin of corticosteroids, phenytoin, carbamazepine, noradrenaline, azathioprine, theophylline, calcium chloride.