Veagra 50 - Tablet Sildenafil - 50mg 1 Tablet(s) / Tablet Astra Biopharmaceuticals Ltd. Introduction: Veagra 50 is a prescription medicine used to treat erectile dysfunction (impotence) in men. It works by increasing blood flow to the penis. This helps men to get or maintain an erection. It belongs to a group of medicines known as phosphodiesterase type 5 (PDE 5) inhibitors. Veagra 50 may be taken on an empty stomach or with a meal. It should be strictly taken as advised by your doctor. You should take it about 1 hour before you plan to have sex. The amount of time it takes to work varies from person to person, but it normally takes... Uses of Veagra 50: Erectile dysfunction Side effects of Veagra 50: Flushing (sense of warmth in the face, ears, neck and trunk)HeadacheBlurred visionMuscle painUpset stomachAltered visionRash How to use Veagra 50: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Veagra 50 may be taken with or without food, but it is better to take it at a fixed time. How Veagra 50 works: Veagra 50 is a phosphodiesterase-5 (PDE-5) inhibitor. It works by relaxing the blood vessels in your penis, thereby increasing blood flow into the penis on sexual stimulation. This helps you achieve and maintain a hard, erect penis suitable for sexual activity. What if you forget to take Veagra 50?: If you miss a dose of Veagra 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Erectile dysfunction, Pulmonary arterial hypertension Administration: May be taken with or without food. Adult Dose: Oral Erectile dysfunction Adult: 50 mg about 1 hr before sexual intercourse. May adjust dose depending on penile response. Max: 100 mg/dose and not to be taken > once in 24 hr. Elderly: >65 yr: Lower initial dose at 25 mg. Hepatic impairment: Initially, 25 mg. Pulmonary Arterial Hypertension 20 mg 3 times daily, administered 4-6 hours apart Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Initially, 25 mg. Contraindication: Hypersensitivity. Patients concurrently or intermittently using organic nitrates in any form. Mode of Action: Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for cGMP degradation in the corpus cavernosum. Inhibition of PDE5 increases cGMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Precaution: Caution when used in patients with anatomical deformation of penis or conditions that may predispose them to priapism (e.g. sickle cell anaemia, myeloma, or leukaemia). Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur. Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders. May cause sudden loss or decrease in hearing. Side Effect: >10% Headache (7-16%) 1-10% Flushing (4-10%),Epistaxis (8%),Dyspepsia (4-8%),Insomnia (6%),Erythema (5%),Diarrhea (4%),Dizziness (2%),Skin rash (2%) Interaction: Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Symptomatic hypotension when used with beta-blockers. Plasma concentrations are increased by ritonavir. Potentially Fatal: May potentiate hypotensive effects of of organic nitrates and nicorandil.