Vastarel MR - tablet Trimetazidine Dihydrochloride - 35mg 30 Tablet(s) / Strip Servier Bangladesh Operation Introduction: Vastarel MR is an anti-anginal medicine used for treating heart-related chest pain (angina). It prevents new attacks of angina but does not stop an acute attack once it has started. It can be used alone or in combination with some other medicines. Vastarel MR should be taken regularly as advised by the doctor. You should take it with or without food and at a fixed time. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the... Uses of Vastarel MR: Angina (heart-related chest pain) Side effects of Vastarel MR: ConstipationDizzinessHeadacheNauseaVomitingWeakness How to use Vastarel MR: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vastarel MR may be taken with or without food, but it is better to take it at a fixed time. How Vastarel MR works: Vastarel MR is an anti-anginal medication. It decreases the oxygen requirement of the heart by shifting its metabolism from fats to glucose. As a result, the heart works more efficiently. What if you forget to take Vastarel MR?: If you miss a dose of Vastarel MR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Ischaemic heart disease, Angina pectoris, Coronary heart disease Administration: Should be taken with food. Adult Dose: Oral Angina pectoris Adult: 40-60 mg daily in 2-3 divided doses. Modified-release tab: 35 mg bid. Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Contraindicated. 30-60 20 mg bid. Modified-release: 35 mg once daily. Contraindication: Hypersensitivity to Trimetazidine Dihydrochloride. Mode of Action: Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance. Precaution: Moderate renal impairment (CrCl 30-60 mL/min). Pregnancy. Patient Counselling May cause dizziness and drowsiness, if affected, do not drive or operate machinery. Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use in pregnant women is not recommended. It is not known whetherTrimetazidine passes into breast milk or not. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants. Side Effect: Dizziness, headache, abdominal pain, dyspepsia, diarrhoea, nausea, vomiting, pruritus, rash, urticaria, asthenia. Rarely, tachycardia, palpitations, extrasystoles, orthostatic hypotension, arterial hypotension, flushing. Interaction: MAOIs, nifedipine. May potentiate the effects of other antianginals.