Valsan - Capsule Valsartan - 80mg 1 Capsule(s) / Capsule Mystic Pharmaceuticals Ltd. Introduction: Valsan is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Valsan can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most... Uses of Valsan: Hypertension (high blood pressure)Heart failurePrevention of heart attack and stroke Side effects of Valsan: HeadacheDizzinessFlu-like symptomsStomach painDecreased blood pressureDiarrheaBack painRashIncreased creatinine level in blood How to use Valsan: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Valsan may be taken with or without food, but it is better to take it at a fixed time. How Valsan works: Valsan is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently. What if you forget to take Valsan?: If you miss a dose of Valsan, skip it and continue with your normal schedule. Do not double the dose. Indication: Heart failure, Hypertension, Post myocardial infarction Administration: May be taken with or without food. Adult Dose: Oral Hypertension Adult: Initially, 80 mg once daily, may be increased to 160 mg once daily if needed. Max: 320 mg once daily. Heart failure Adult: Initially, 40 mg bid, may be increased to 160 mg bid if tolerated. Post myocardial infarction Adult: Start as early as 12 hr after MI in stable patients at an initial dose of 20 mg bid, doubled at intervals over a few wk up to 160 mg bid if tolerated. Elderly: No dosage adjustment needed. Hepatic impairment: Mild to moderate: Max: 80 mg once daily. Severe: Contraindicated. Child Dose: Oral Hypertension Child: As tab: >6 yr 80 kg: Initially, 80 mg once daily. Max: 320 mg once daily. Renal Dose: Renal impairment CrCl >30 mL/min: No dose adjustment necessary in adults CrCl <30 mL/min: Use with caution in adults; not studied in children Contraindication: Hypersensitivity; severe hepatic impairment, cirrhosis or biliary obstruction; primary hyperaldosteronism. Pregnancy (2nd and 3rd trimesters) and lactation. Mode of Action: Valsartan, an angiotensin II type 1 (AT1) receptor antagonist, produces its BP lowering effects by inhibiting angiotensin II-induced vasoconstriction, aldosterone release and renal reabsorption of Na. Precaution: Patients w/ renal artery stenosis, heart failure, aortic or mitral stenosis, severe Na and/or volume depletion. Renal and mild to moderate hepatic impairment. Lactation. Monitoring Parameters Monitor BP, electrolytes, renal function. Monitor serum K levels every dose increment and periodically thereafter. Side Effect: >10% Dizziness (17%; heart failure),Increased blood urea nitrogen (BUN; 17%) 1-10% Hyperkalemia (4-10%),Dizziness (2-8%; hypertension),Hypotension (1-7%; heart failure),Fatigue (3%),Viral infection (3%),Neutropenia (2%),Syncope (>1%),Upper abdominal pain (>1%),Vertigo (>1%) Frequency Not Defined Headache,Cough (rare) Potentially Fatal: Blood dyscrasias (e.g. neutropenia). Interaction: May antagonise hypotensive effects and increase the risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics, K supplements or K-containing salt substitutes. Potentially Fatal: Increased risk of hypotension, hyperkalemia and changes in renal function (including acute renal failure) when used w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).