Uriten - Tablet Alfuzosin - 10mg 1 Tablet(s) / Tablet Square Pharmaceuticals PLC. Introduction: Uriten is an alpha adrenergic antagonist that is used in the treatment of benign prostatic hyperplasia. It helps to relieve symptoms like difficulty in passing urine. However, it does not decrease the size of the prostate. Uriten is advised to take it in a dose and duration as per prescription. It should be taken with food, but take at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment... Uses of Uriten: Benign prostatic hyperplasia Side effects of Uriten: DizzinessHeadacheTiredness How to use Uriten: Use it as advised by your doctor or check the label for directions before use. Uriten is to be taken with food. How Uriten works: Uriten is an alpha blocker. It works by relaxing muscle around the bladder exit and prostate gland so urine is passed more easily. What if you forget to take Uriten?: If you miss a dose of Uriten, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Oral Benign prostatic hyperplasia Adult: 2.5 mg tid. Max: 10 mg/day. 1st dose should be given before bedtime. Extended-release: 10 mg once daily. Elderly: Initially, 2.5 mg bid. Acute urinary retention: Extended-release: 10 mg once daily to be taken from 1st day of catheterisation. Duration: 3-4 days. Hepatic impairment: Mild to moderate: Initially, 2.5 mg daily, may increase to 2.5 mg bid according to response. Severe: Contraindicated. Administration: Additive effect on QT interval prolongation when used w/ QT-prolonging drugs. Concomitant admin w/ other ?1-adrenergic blocking agents, atenolol or diltiazem may result in additive CV effects. Increased plasma alfuzosin concentrations w/ cimetidine. Potentially Fatal: Concurrent use w/ potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir) increase plasma alfuzosin levels. Adult Dose: Elderly; hypertension; coronary insufficiency; angina (discontinue); renal or hepatic impairment. Monitor BP regularly. May affect ability to drive or operate machinery. Renal Dose: Alfuzosin is a quinazoline derivative which exhibits selectivity for alpha1-adrenergic receptors in the lower urinary tract. Blockade of these adrenoreceptors causes relaxation of smooth muscle in the bladder neck and prostate, resulting in improvement in urine flow and a reduction in symptoms of benign prostatic hyperplasia (BPH). Mode of Action: Administration Should be taken with food. Swallow whole. Extended-Release: Should be taken with food. Take immediately after the same meal each day. Swallow whole, do not chew/crush. Precaution: Benign prostatic hyperplasia (BPH) Side Effect: Renal Impairment Initially, 2.5 mg bid. Adjust dose according to response. Pregnancy Category Note: 1-10% Abdominal pain (1-2%),Back pain (1-2%),Brochitis (1-2%),Constipation (1-2%),Dizziness (5.7%),Dyspepsia (1-2%),Fatigue (2.7%),Headache (3%),Impotence (1-2%),Nausea (1-2%),Pharyngitis (1-2%),URT infection (3%),Sinusitis (1-2%),Upper respiratory infection (3%) Interaction: Severe hepatic impairment; history of postural hypotension and micturition syncope; intestinal occlusion; severe renal insufficiency; lactation.