Urifen 400 - Tablet Dexibuprofen - 400mg 4 Tablet(s) / Strip Unknown Introduction: Urifen 400 is a pain relieving medicine. It is used for symptomatic treatment of pain and inflammation associated with osteoarthritis, pain during menstruation, and other muscular-skeletal or dental pain. Urifen 400 can be taken with food, preferably with a glass of water. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. The most common side effects of this medicine include mild indigestion, diarrhea, nausea, vomiting, stomach pain,... Uses of Urifen 400: Pain relief Side effects of Urifen 400: VomitingStomach painNauseaIndigestionHeartburn How to use Urifen 400: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Urifen 400 is to be taken with food. How Urifen 400 works: Urifen 400 is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Indication: Osteoarthritis, Pain, Fever, Pericarditis, Dysmenorrhea, Rheumatic disorders, Patent ductus arteriosus Adult Dose: Oral Pain and inflammation associated with musculoskeletal and joint disorders ; Dysmenorrhoea Adult: 600-900 mg daily in 2-3 divided doses. May increase to 1200 mg daily for patients with acute conditions or exacerbations. Max Dosage: 400 mg/dose and 1200 mg/day. Hepatic impairment: Dose reduction is recommended. Renal Dose: Renal impairment: Dose reduction is recommended. Contraindication: Hypersensitivity to aspirin or NSAIDs; active or suspected GI ulcer or history of recurrent GI ulcer; GI bleeding or other active bleedings or bleeding disorders; active Crohn's disease or ulcerative colitis; haemorrhagic diasthesis and other coagulation disorders, or patients receiving anticoagulant therapy; severe heart failure, renal or hepatic impairment; child <18 yrs; pregnancy (third trimester). Mode of Action: Dexibuprofen is a NSAID. It acts by inhibition of cyclo-oxygenase, which is involved in prostaglandin synthesis. Precaution: History of bronchial asthma; renal or hepatic disorders; bleeding disorders; CV disease; elderly; lactation. Side Effect: GI bleeding, heartburn, epigastric pain; dyspepsia, peptic ulcer; nausea, vomiting, diarrhoea; jaundice, hepatitis; rash; thrombocytopaenia; visual disturbances; tinnitus; depression; fatigue, headache, dizziness, vertigo. Interaction: Avoid concomitant use with anticoagulants, other NSAIDs and salicylates. Increases risk of methotrexate and lithium toxicity.