Urbifen 50 - Tablet Flurbiprofen - 50mg 10 Tablet(s) / Strip General Pharmaceuticals Ltd. Introduction: Urbifen 50 is a pain relieving medicine. It is used to treat pain, swelling, and stiffness caused by conditions such as osteoarthritis and rheumatoid arthritis. Urbifen 50 is only meant for external use and should be used strictly as advised by your doctor. A thin layer of the medicine should be massaged into the affected areas with clean and dry hands. Avoid getting in contact with your eyes, nose, or mouth and avoid applying it on wounded or damaged skin. In case of accidental contact, you should rinse it thoroughly with plenty of water. It is usually safe with little... Uses of Urbifen 50 Gel: Pain relief Side effects of Urbifen 50 Gel: No common side effects seen How to use Urbifen 50 Gel: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area. How Urbifen 50 Gel works: Urbifen 50 is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Indication: Dysmenorrhoea, Sore throat, Ocular inflammation, Pain and inflammation associated w/ musculoskeletal and joint disorders, Prophylaxis of miosis during ocular surgery Administration: Should be taken with food. Adult Dose: Oral Pain and inflammation Adult: 150-200 mg daily in divided doses, increased to 300 mg daily in acute or severe conditions if necessary. Dysmenorrhoea Adult: Initially, 100 mg followed by 50-100 mg 4-6 hrly. Max: 300 mg daily. Rheumatoid Arthritis, Osteoarthritis 200-300 mg/day divided q6-12hr PO, not to exceed 100 mg/dose or 300 mg/day Child Dose: <12 years: Not recommended Renal Dose: Renal Impairment Severe Impairment: Not recommended Contraindication: Peptic ulcer, GI haemorrhage, asthma, bronchospasm, rhinitis, angioedema, hypersensitivity; aspirin intolerance; pregnancy (3rd trimester); lactation. Mode of Action: Flurbiprofen inhibits prostaglandin synthesis by decreasing the activity of cyclooxygenase resulting in reduced prostaglandin levels. It is also a potent inhibitor of platelet aggregation. Precaution: Patients w/ known CV disease or risk factors for CV disease, fluid retention. Hepatic and renal impairment. Lactation. Lactation: excreted in breast milk; not recommended Side Effect: Oedema, abdominal pain, constipation, diarrhoea, dyspepsia/heartburn, liver enzyme elevations, flatulence, nausea, vomiting, wt change, headache, nervousness, CNS stimulation (e.g. anxiety), CNS inhibition (e.g. somnolence), rhinitis, vision changes, dizziness/vertigo, tinnitus, signs and symptoms of UTI, rash. Ocular hyperaemia, eye irritation, fibrosis, miosis, mydriasis. Potentially Fatal: GI bleeding, ulceration and perforation, jaundice, fulminant hepatitis, liver necrosis, hepatic failure. Pregnancy Category Note: Pregnancy Category: C; avoid in late pregnancy Lactation: excreted in breast milk; not recommended Interaction: Reduced antihypertensive effect of ACE inhibitors, angiotensin II receptor antagonists and ?-blockers. Slight reduction in blood glucose concentration in patients w/ DM receiving certain antidiabetic agents (e.g. glyburide, metformin). Reduced diuretic effect of furosemide and thiazides. May increase toxicity of lithium and methotrexate. May increase risk of bleeding w/ antiplatelets, anticoagulants, SSRIs, corticosteroids.