Ucol 2 - Tablet Tolterodine Tartrate - 2mg 10 Tablet(s) / Strip Square Pharmaceuticals PLC. Introduction: Ucol 2 is used in the treatment of overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination. Ucol 2 is advised to take it in a dose and duration as per prescription. It can be taken with or without food, but take it at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy... Uses of Ucol 2: Overactive bladder (OAB) symptoms Side effects of Ucol 2: Dryness in mouthConstipationHeadacheDizzinessSleepinessBlurred visionDry skin How to use Ucol 2: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ucol 2 may be taken with or without food, but it is better to take it at a fixed time. How Ucol 2 works: Ucol 2 is an antimuscarinic. It works by relaxing muscles of the urinary bladder and prevents frequent, urgent or uncontrolled urination. What if you forget to take Ucol 2?: If you miss a dose of Ucol 2, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Overactive bladder Adult Dose: Oral Overactive Bladder, Urge Incontinence Immediate release: 2 mg PO q12hr. Reduce to 1 mg bid if needed to reduce side effects. Extended release: 2-4 mg PO once daily Hepatic impairment Mild to moderate (Child-Pugh class A or B): Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release) Severe (Child-Pugh class C): Not recommended Child Dose: Child < 18 years: Not recommended Renal Dose: Renal impairment CrCl 10-30 mL/min: Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release) CrCl <10 mL/min: Not recommended Contraindication: Severe ulcerative colitis, toxic megacolon, urinary retention, gastric retention, myasthenia gravis, uncontrolled narrow-angle glaucoma, pregnancy. Mode of Action: Tolterodine is a competitive muscarinic receptor antagonist with actions similar to atropine. It is used in the management of urge urinary incontinence, urgency and frequency. Precaution: Bladder flow obstruction, GI obstructive disorders, renal or hepatic impairment, autonomic neuropathy, hiatus hernia, risk of decreased GI motility, patients at risk of QT interval prolongation (e.g. electrolyte disturbances, bradycardia, pre-exisiting cardiac disorder). Lactation: Unknown whether drug is distributed in breast milk; do not nurse Side Effect: >10% Dry mouth (40%) 1-10% Blurred vision,Constipation,Dizziness,Drowsiness,Dyspepsia,Headache,Xerophthalmia Interaction: Increased risk of overdosage with potent CYP3A4 inhibitors e.g. macrolide antibiotics (erythromycin and clarithromycin), azole antifungals (e.g. ketoconazole and itraconazole), protease inhibitors, ciclosporin or vinblastine. Increased risk of torsade de pointes with drugs that prolong the QT interval (e.g. class Ia and class III antiarrhythmics). Increased risk of 'cholinergic neurogenic hypersensitivity' with centrally acting anticholinesterases (e.g. donepezil, rivastigmine). Increased risk of antimuscarinic side effects with antimuscarinic drugs.