Trecilon - Injection Triamcinolone Acetonide - 40mg/ml 1 Injection(s) / Injection Rephco Pharmaceuticals Ltd. Introduction: Trecilon is a steroid. It is used for treatment of wide variety of medical conditions such as allergic disorders, severe allergic reactions, and rheumatic disorders. It provides relief by preventing the release of substances that cause inflammation and by suppressing the immune system. Trecilon is given by a doctor or a healthcare professional. You should not self-administer this medicine at home. Using the medicine regularly at the right times increases its effectiveness. It is important to keep using the medicine regularly until your doctor tells you it is safe to stop. Trecilon may cause few side effects such as infection,... Uses of Trecilon: Allergic disordersSevere allergic reactionsRheumatic disorder Side effects of Trecilon: HeadacheInfectionJoint pain How to use Trecilon: Your doctor or nurse will give you this medicine. Kindly do not self administer. How Trecilon works: Trecilon is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies. Indication: Allergic and inflammatory responses, Inflammatory joint disease, Inflammatory skin conditions Administration: Dilute with local anesthetic (1% or 2% lidocaine without parabens) before intra-articular or intralesional injection Dilute with D5/NS or D10/NS or NS or SWI before intralesional injection Adult Dose: Intramuscular Suppression of allergic and inflammatory disorders Adult: As acetonide: 20-80 mg via deep IM into gluteal muscles. Symptomatic control for hay fever Adult: As acetonide: 40-100 mg via deep IM into gluteal muscles. Rheumatic or arthritic disorders Adult: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM PRN Intra-articular Inflammatory joint diseases Adult: As acetonide: Smaller joints: 2.5-5 mg (up to 10 mg), larger joints: 5-15 mg (up to 40 mg). Max: 20-80 mg/treatment. Intradermal Inflammatory skin conditions Adult: As acetonide: 1-3 mg/site. Max: 30 mg in total if several sites of inj used.... Child Dose: Intramuscular Suppression of allergic and inflammatory disorders Child: As acetonide: deep IM into gluteal muscle: initial 0.11 to 1.6 mg/kg/day in 3-4 divided doses. Do not use in premature infants and infants of low birth weight as it contains benzyl alcohol. Child: 6-12 years: 0.03-0.2 mg/kg IM every 1-7 days >12 years: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM PRN >12 years, intralesional injection (10 mg/mL suspension): 1 mg per injection site 1 or more times weekly; not to exceed 30 mg/day Symptomatic control for hay fever Child: As acetonide: deep IM into... Contraindication: Triamcinolone Acetonide is contraindicated in patients with a sensitivity to the active or inactive ingredients. Untreated systemic fungal, bacterial, viral or parasitic infection, hypersensitivity. Neonates (Parenteral) Mode of Action: Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation. Precaution: Diabetes; hypertension, renal and liver impairment; glaucoma; psychosis; delayed tissue healing; cirrhosis; heart failure; recent MI; hypothyroidism; osteoporosis; peptic ulceration; thromboembolic disorders. Monitor height in children on prolonged therapy. Avoid rapid drug withdrawal. Elderly, children, pregnancy, lactation. Lactation: Excreted in breast milk; use caution Side Effect: HPA axis supression, intracranial hypertension, Cushing's syndrome, growth retardation in children; osteoporosis, fractures. Peptic ulceration; glaucoma; hyperglycaemia; GI upsets; increased appetite; increased fragility of skin; behavioural changes. Potentially Fatal: Acute adrenal insufficiency may be precipitated by infection or trauma in patients on long-term corticosteroid therapy or rapid withdrawal. Interaction: Lowering of plasma salicylates levels. Increased risk of GI bleeding and ulceration with NSAIDs. Antagonised blood glucose-lowering effects of the antidiabetics. Increased risk of hyperkalaemia with amphotericin B, beta agonists, beta-blockers, potassium-depleting diuretics, theophylline. Increased clearance of the triamcinolone with ciclosporin, carbamazepine, phenytoin, barbiturate, rifampicin. Infections may develop if given with live vaccines.