Timosol - Eye Drop Timolol Maleate 0.5% Eye prep - 0.50% 1 5ml drop(s) / 5ml drop Rephco Pharmaceuticals Ltd. Introduction: Timosol is a beta-blocker used to treat elevated intraocular pressure (high pressure inside the eye) in people with ocular hypertension or open angle glaucoma. It lowers the pressure in the eye by decreasing the production of fluid and reduces the risk of vision loss. Always wash your hands before using Timosol. Use only the number of drops that your doctor has prescribed and wait for about 5 minutes between each drop. If you wear soft contact lenses, remove them before using the drops and wait for at least 15 minutes before putting them back in. If you are also using... Uses of Timosol: GlaucomaOcular hypertension Side effects of Timosol: Burning eyesStinging in the eyes How to use Timosol: This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. How Timosol works: Timosol is a beta blocker. It works by decreasing the production of aqueous humour (fluid in the eye), thereby lowering the increased eye pressure. What if you forget to take Timosol?: If you miss a dose of Timosol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Open-angle glaucoma, Ocular hypertension Adult Dose: Ophthalmic Open-angle glaucoma; Ocular hypertension Adult: Initial: The usual starting dose is one drop in the affected eye(s) twice a day. Reduce to 1 drop/day if controlled. Child Dose: Safety & efficacy not established Contraindication: Hypersensitivity to any component of this product; bronchial asthma; history of bronchial asthma; severe chronic obstructive pulmonary disease; sinus bradycardia; second or third degree atrioventricular block; overt cardiac failure; cardiogenic shock Mode of Action: Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP. Precaution: Observe patients receiving topical timolol and a systemic ß-adrenergic blocking agent concomitantly for potential additive effects on IOP and/or systemic effects of ß-adrenergic blockade Severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, reported following systemic or ophthalmic administration of timolol maleate Patients with chronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema) of mild or moderate severity, bronchospastic disease, or a history of bronchospastic disease (other than bronchial asthma or a history of bronchial asthma, in which timolol is contraindicated) should, in general, not receive beta-blockers... Side Effect: >10% Burning or stinging (38%) >1% Blurred vision (4-10%),Cataract (4-10%),Conjunctivitis (4-10%),Decreased visual acuity (4-10%),Headache (4-10%),Hypertension (4-10%),Infection (4-10%),Itching (4-10%) Frequency Not Defined Ocular irritation,Blepharitis,Keratitis,Ocular pain,Discharge (e.g., crusting),Foreign body sensation,Dry eyes,Eyelid erythema,Blepharoptosis,Decreased corneal sensitivity,Diplopia,Cystoid macular edema,Pseudopemphigoid,Choroidal detachment following filtration surgery,Epiphora,Photophobia,Conjunctival injection,Corneal fluorescein staining,Retinal vascular disorder,Ptosis Potentially Fatal: Heart failure, intensification of heart block, bronchospasm, respiratory failure. Interaction: Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive effects w/ other antihypertensives (e.g. hydralazine, methyldopa). Increased beta-adrenergic blockade (e.g. decreased heart rate) w/ quinidine. Rebound HTN due to abrupt withdrawal of clonidine. Hypotensive effect may be antagonised by NSAIDs (e.g. indomethacin, ibuprofen).