Texifen 250 - tablet Terbinafine - 250mg 7 Tablet(s) / Box Leeford Healthcare Ltd Introduction: Texifen 250 is used to treat a wide range of fungal infections of the skin and nails, including ringworm. It works by killing the fungus that causes the infection. Texifen 250 is for external use only. It should be used in the dose and duration suggested by the doctor. Applying it at the same time every day will help you remember to use it. The affected area should be clean and dry before application of the ointment. You must wash your hands thoroughly before and after applying this medicine. Do not stop using it until you have finished the complete... Uses of Texifen 250: Fungal skin infections Side effects of Texifen 250: Skin peeling How to use Texifen 250: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. How Texifen 250 works: Texifen 250 is an antifungal medication which treats skin infections. It works by killing the fungi on the skin by destroying their cell membrane. What if you forget to take Texifen 250?: If you miss a dose of Texifen 250, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections Administration: May be taken with or without food. Adult Dose: Oral Onychomycosis Adult: 250 mg once daily for 6 weeks (fingernail) or 12 weeks (toenail) Tinea Pedis, Tinea Corporis, Tinea Cruris Adult: 250 mg/day PO in single dose or divided q12hr 2-4 wk in tinea cruris, tinea corporis 2-6 wk for tinea pedis Hepatic impairment: Use not recommended in chronic or active liver disease Child Dose: Tinea Capitis >4 years (4 years (25-35 kg): 187.5 mg/day PO for 6 weeks >4 years (>35 kg): 250 mg/day PO for 6 weeks Renal Dose: Renal impairment: Use not recommended if CrCl <50 mL/min Contraindication: Hypersensitivity, active or chronic liver disease, lactation. Mode of Action: Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast. Precaution: Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy. Lactation: Drug excreted in breast milk; do not use Side Effect: >10% Headache (13%) 1-10% Rash (6%),Pruritus (3%),Nausea (3%),Diarrhea (6%),Dyspepsia (4%),Abdominal pain (2%),Taste disturbance (3%),Elevated liver function test results (3%),Visual disturbance (1%) Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia. Interaction: Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.