Tetrasina - Capsule Tetracycline Hydrochloride - 250mg 10 Capsule(s) / Strip The Ibn Sina Pharmaceutical Ind. Ltd. Introduction: Tetrasina is an antibiotic medicine used to treat bacterial infections in your body. It is effective in some infections of the lungs, urinary tract, eyes, and others. It kills bacteria, which helps to improve your symptoms and cure the infection. Tetrasina is also used to treat many sexually transmitted diseases. It should be taken on an empty stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being... Uses of Tetrasina: Bacterial infections Side effects of Tetrasina: PhotosensitivityVomitingNauseaDiarrhea How to use Tetrasina: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Tetrasina is to be taken empty stomach. How Tetrasina works: Tetrasina is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions. Indication: Acne, Lyme disease, Uncomplicated gonorrhea, Syphilis, Psittacosis, Q fever, Pleural effusions, Rocky Mountain spotted fever, Lymphogranuloma venereum, Mycoplasma pneumoniae, Trachoma, Nongonococcal urethritis Administration: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals w/ a full glass of water, in upright position. May be taken w/ meals to reduce GI discomfort. Adult Dose: Oral Susceptible infections Adult: 250-500 mg 6 hrly. Max: 4 g/day. Acne Adult: 250-500 mg daily, in divided doses, for at least 3 mth. Syphilis Adult: 500 mg 4 times daily for 15 days. Gonorrhoea Adult: 500 mg 4 times daily for 7 days. Vibrio Cholera Adult: 500 mg 4 times daily for 3 days Brucellosis Adult: 500 mg 4 times daily for 3 wk in combination w/ streptomycin. Hepatic impairment: Max: 1 g daily. Child Dose: Oral Children : 8 y: 25–50 mg/kg/day q6h not to exceed 3 g/day Renal Dose: Renal impairment CrCl 50-80 mL/min: Dose frequency q8-12hr CrCl 10-50 mL/min: Dose frequency q12-24hr CrCl <10 mL/min: Dose frequency q24hr Contraindication: Hypersensitivity; pregnancy, lactation, children; renal impairment. Mode of Action: Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa. Precaution: Patient w/ pre-existing SLE, myasthenia gravis. Hepatic and mild to moderate renal impairment. Pregnancy. Patient Counselling Avoid direct exposure to sunlight or UV light. Monitoring Parameters Monitor renal, hepatic and haematologic function test, temp, WBC, cultures and sensitivity, appetite, mental status. Side Effect: >10% Discoloration of teeth and enamel hypoplasia (young children) 1-10% Diarrhea,Nausea,Photosensitivity <1% Anorexia,Abdominal cramps,Antibiotic-associated pseudomembranous colitis,Bulging fontanels in infants,Diabetes insipidus syndrome,Esophagitis,Exfoliative dermatitis,Incr ICP,Pericarditis,Pseudotumor cerebri,Pancreatitis,Pruritus,Pigmentation of nails,Vomiting Potentially Fatal: Anaphylaxis, hepatotoxicity, nephrotoxicity, blood dyscrasias. Interaction: Impaired absorption w/ antacids containing divalent and trivalent cations (e.g. Al, Ca, Mg), Fe, Zn and Na bicarbonate preparations, kaolin-pectin, bismuth subsalicylate, sucralfate, strontium ranelate, colestipol and colestyramine. May interfere w/ the bactericidal action of penicillin. May potentiate the effect of anticoagulants. May decrease efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients w/ DM. May increase toxic effects of ergot alkaloids and methotrexate. Potentially Fatal: Concurrent methoxyflurane may result to fatal renal toxicity. Increased risk of benign intracranial HTN w/ vit A...