Tenbee - Tablet Tenofovir Disoproxil Fumarate - 300mg 6 Tablet(s) / Strip Jenphar Bangladesh Ltd. Introduction: Tenbee is used to treat HIV infection and chronic hepatitis B virus (HBV) infection in combination with other anti-HIV medicines. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. Tenbee is not a cure for HIV/AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It may also be used to prevent HIV infection in some people at high risk. This medicine is best taken with food. It is used... Uses of Tenbee: HIV infectionChronic hepatitis B virus (HBV) infection Side effects of Tenbee: RashWeaknessNauseaStomach painDiarrhea How to use Tenbee: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tenbee is to be taken with food. How Tenbee works: Tenbee is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. What if you forget to take Tenbee?: If you miss a dose of Tenbee, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: HIV-1 infection, Chronic hepatitis B Administration: May be taken with or without food. Take consistently either always w/ or always w/o food. Adult Dose: Oral Chronic hepatitis B; HIV infection (Indicated in combination with other antiretroviral agents for treatment of HIV-1 infection) Adult: 300 mg once daily. Child Dose: HIV Infection 2 years: 8 mg/kg PO qDay; not to exceed 300 mg/day Hepatitis B Infection 12 years; 12 years; >35 kg: 300 mg PO qDay Renal Dose: Renal impairment: Haemodialysis patients: 300 mg once every 7 days or after a cumulative total of 12 hr of dialysis. CrCl (ml/min) Dosage Recommendation 10-29 300 mg 72-96 hrly. 30-49 300 mg 48 hrly. Contraindication: Tenofovir is contraindicated in patients with previously demonstrated hypersensitivity to Tenofovir or any component of the product. Mode of Action: Tenofovir disoproxil fumarate, a diester prodrug of tenofovir, is a nucleotide reverse transcriptase inhibitor. After oral absorption, tenofovir disoproxil fumarate is rapidly converted to tenofovir and then undergo subsequent phosphorylation by cellular enzymes to the active tenofovir diphosphate, which inhibits the activity of HIV-1 reverse transcriptase. Precaution: Patient w/ hepatomegaly or other risk factors for liver disease. Renal impairment. Pregnancy. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor renal function and serum phosphate concentrations before start of therapy, 4 wkly during the 1st wk, and then 3 mthly; hepatic function for several mth following discontinuation. Determine HIV status in all hepatitis B virus (HBV) infected patients prior to treatment. Lactation: HIV+ women are advised not to breastfeed Side Effect: >10% Asthenia (11%),Diarrhea (16%),Nausea (11%),Pain (12%) 1-10% Anorexia,Depression,Myalgia,Peripheral neuropathy,Dyspepsia,Rash,Headache,Vomiting,Flatulence,Abdominal pain,Neutropenia,Increased transaminases Interaction: Decreased atazanavir concentration with tenofovir unless also co-administered with ritonavir. Increased serum concentration of tenofovir or co-administered drug if taken with drugs that are eliminated by active tubular secretion. Potentially Fatal: Increased risk of renal impairment with recent or concurrent use of nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2); monitor renal function wkly if unavoidable. Increased didanosine levels and thereby increasing risk of pancreatitis and peripheral neuropathy, with a high treatment failure rate with concurrent use; avoid concurrent use.