Sudofen - Tablet Pseudoephedrine Hydrochloride - 60mg 1 Tablet(s) / Tablet Virgo Pharmaceuticals Ltd. Indication: Nasal congestion Administration: May be taken with or without food. Adult Dose: Oral Nasal congestion Adult: 1 tablet (60 mg) every 4-6 hr. Max: 4 tab in 24 hr. Child Dose: Oral Nasal congestion Children : 6 - 12 years of age: 1/2 tablet (30 mg) 3-4 times daily. 2 - 5 years of age: 1/4 tablet (15 mg) every 3-4 times daily. Contraindication: Hypersensitivity, Severe hypertension and coronary artery disease, Concurrent use of Mono Amine Oxidase Inhibitor (MAOI) drugs. Mode of Action: Pseudoephedrine is both an alpha-and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. It also directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility. Precaution: Hyperthyroidism; ischaemic heart disease, arrhythmia or tachycardia; occlusive vascular disorders e.g. arteriosclerosis, hypertension or aneurysms; DM and closed-angle glaucoma; renal impairment, prostatic enlargement. Pregnancy; lactation. Lactation: Concentrated in breast milk, Mfr contraindicates (AAP Committee states compatible with nursing) Side Effect: Anginal pain; rebound congestion and rhinorrhoea; fear, anxiety, restlessness, tremor, insomnia, confusion, irritability and psychotic states; reduced appetite, nausea, vomiting; gangrene; cerebral haemorrhage and pulmonary oedema; reflex bradycardia, tachycardia and cardiac arrhythmias, palpitations and cardiac arrest, hypotension and dizziness, fainting and flushing. Tissue necrosis and sloughing; myocardial and arterial necrosis. Interaction: Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.