SRT Vaginal Cream - cream Estriol - 0.1% 1 15gm tube(s) / 15gm tube Healthcare Pharmaceuticals Ltd. Introduction: SRT Vaginal Cream is identical to a female hormone, estrogen. It is used to treat symptoms associated with menopause. This topical preparation helps to treat vaginal burning, dryness and itching caused due to lack of estrogen. You should use SRT Vaginal Cream in the way your doctor advises. It may depend on whether you have had any kind of HRT before. Even if your symptoms improve, you should continue the treatment as it has been prescribed. When you start using this medicine you may experience irritation or itching. This usually goes away if you continue using it. You may also... Side effects of SRT Vaginal Cream: Vaginal irritation How to use SRT Vaginal Cream: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream by using applicator. Wash your hands after applying. How SRT Vaginal Cream works: SRT Vaginal Cream contains oestrogen (female sex hormone). It works by delivering estrogens directly into the vagina to relieve vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Indication: Infertility due to cervical hostility, Menopausal atrophic vaginitis, Menopausal hormone replacement therapy, Dyspareunia, Dryness and itching of vagina due to Oestrogen deficiency, Prevention of recurrent infections of the vagina and lower urinary tract, Micturition complaints (such as frequency and dysuria), Urinary incontinence. Pre- and postoperative therapy in postmenopausal women undergoing vaginal surgery, Climacteric complaints such as hot flushes and night sweating, a diagnostic aid in case of a doubtful atrophic cervical smear. Administration: Tablet: May be taken with or without food. Adult Dose: Oral Menopausal hormone replacement therapy Adult: 0.5-3 mg daily for 1 mth followed by 0.5-1 mg daily; or 0.25-2 mg daily in combination with other natural oestrogens. A progestogen is required if administered to women with a uterus. Infertility due to cervical hostility Adult: 0.25-1 mg/day on days 6-15 of the menstrual cycle. Increase dose each mth until an optimal effect is obtained. Vaginal Menopausal atrophic vaginitis Adult: As cream: Apply 500 mcg once daily, reduce to twice wkly subsequently. Contraindication: • Pregnancy • Known, past or suspected breast cancer • Known or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer) • Undiagnosed genital bleeding • Untreated endometrial hyperplasia • Previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism) • Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction) • Acute liver disease, or a history of liver disease as long as liver function tests failed to return to normal Mode of Action: Estriol is a naturally occurring oestrogen. It induces normalization of vag epithelium. It is claimed to have only a mild proliferative effect on the endometrium. It only has a short retention time in the nuclei of endometrial cells. Precaution: In order to prevent endometrial stimulation, the daily dose should not exceed 8 mg nor should this maximum dose be used for longer than several weeks. As for all hormone replacement therapies, yearly medical examination is advisable. With vaginal infections, a concomitant specific treatment is recommended. Patients with any of the following conditions should be monitored; thrombosis, severe liver disorders; porphyria; a history during pregnancy or previous use of steroids of severe pruritus, cholestatic jaundice, herpes gestationis, or otosclerosis. Side Effect: Breast tension or pain, nausea, spotting. Fluid retention, cervical hypersecretion. Interaction: Reduced efficacy may occur when used with activated charcoal, barbiturates, carbamazepine, griseofulvin, hydantoin and rifampicin. May possibly change efficacy of oral anticoagulants and increase pharmacologic effects of succinylcholine, theophyllines and troleandromycin.