Soritec 25 - Capsule Acitretin - 25mg 10 Capsule(s) / Box ACI Limited Introduction: Soritec 25 is a medicine that is similar to vitamin A and is involved in the normal growth of skin cells. It is used in the treatment of psoriasis. It works by stopping the overgrowth and thickening of skin cells. Soritec 25 is taken with food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition... Uses of Soritec 25: Psoriasis Side effects of Soritec 25: Dry lipsDryness in mouthSkin peelingJoint painMuscle tightnessCracked lipsItchingChange in finger nailsRunny noseNosebleedsHair lossIncreased levels of blood fat How to use Soritec 25: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Soritec 25 is to be taken with food. How Soritec 25 works: Soritec 25 is a retinoid. It has a structure similar to vitamin A and is involved in the normal growth of skin cells. It works by stopping overgrowth and thickening of skin cells in psoriasis. Indication: Oral Darier's disease Adult: Initially, 10 mg daily for 2-4 wk. Max: 50 mg/day. Congenital icthyosis Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods. Severe psoriasis Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods. Severe lichen planus Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8... Administration: Concomitant use with keratolytics or high dose vitamin A. Reduces anticoagulant effect of coumarins e.g. warfarin. Concomitant use of microdised progestin oral contraceptives. Concomitant use of methotrexate can potentiate hepatotoxicty. Concomitant use with tetracycline. Adult Dose: Female patients to avoid alcohol during and 2 mth after treatment. Avoid blood donation during therapy or at least 1-3 yr after stopping therapy. Children. Radiographic treatment for prolonged therapy. Therapy should not last >6 mth. Monitor plasma lipid and glucose levels (especially diabetics) regularly. Monitor LFTs. Lactation: enters breast milk/not recommended. Renal Dose: Acitretin is an active metabolite of etretinate but its mechanism of action is unknown. Mode of Action: Should be taken with food. Take w/ main meals or w/ a glass of milk. Precaution: Lichen planus, Psoriasis, Congenital icthyosis, Darier's disease Pregnancy Category Note: Cheilitis (>75%),Alopecia (50-75%),Hypertriglyceridemia (50-75%),Skin peeling (50-75%),Dry skin (25-50%),Dysglycemia (25-50%),Increased LFT (25-50%),Nail disorder (25-50%),Pruritus (25-50%),Rhinitis (25-50%),Arthralgia (10-25%),Changes in phosphorus, potassium, sodium, & magnesium levels (10-25%),Dry mouth (10-25%),Epistaxis (10-25%),Erythematous rash (10-25%),Hepatotoxicity (10-25%),Hyperesthesia (10-25%),Paresthesia (10-25%),Paronychia (10-25%),Rigors (10-25%),Skin atrophy (10-25%),Spinal hyperostosis (10-25%),Sticky skin (10-25%),Xerophthalmia (10-25%) 1-10% Edema,Flushing,Depression,Fatigue,Headache,Insomnia,Somnolence,Abdominal pain,Anorexia,Diarrhea,Gingivitis,Increased appetite,Nausea,Stomatitis,Vomiting,Hot flashes,Vision changes,Corneal epithelial abnormality,Sinusitis Potentially Fatal: Phototoxicity, jaundice, hepatitis and hepatotoxity. Interaction: Pregnancy (before the start, during and at least 2-3 yr after cessation of therapy), lactation. Hepatic and renal impairment. Hyperlipidaemia.