Slimfast - Capsule Orlistat - 120mg 12 Capsule(s) / Strip Healthcare Pharmaceuticals Ltd. Introduction: Slimfast is a medicine used in the treatment of obesity. It helps the body in blocking the absorption of fats from the small intestines and stomach. Slimfast should be taken along with food in the dose and duration as per prescription. It must be swallowed as a whole. It works best when it is used along with regular physical activity and healthy diet. It should not be taken for a long term unless your doctor tells you to do so. For better efficacy of the medicine, fat-rich foods should be avoided along with the medicine. Some of the common side... Uses of Slimfast: Obesity Side effects of Slimfast: Abdominal painFat in stoolFlatus with dischargeOily spottingDiarrheaAbdominal crampFlatulenceSoft stools How to use Slimfast: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Slimfast may be taken with or without food, but it is better to take it at a fixed time. Avoid Slimfast with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat. How Slimfast works: Slimfast is a lipase inhibitor. It works in the stomach and small intestine by blocking the absorption of fat from food by blocking enzymes responsible for the breakdown of fat. Indication: Obesity Administration: Should be taken with food. Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted. Adult Dose: Oral Obesity Adult: Indicated in patients with pretreatment BMI >30 kg/m², or BMI >27 kg/m² in presence of other risk factors or diseases (eg, HTN, DM, hyperlipidemia) 120 mg tid w/ each main meal. Patients w/ BMI >28 kg/m2 irrespective of any risk factors: 60 mg tid. Omit dose if a meal is missed or contains no fat. Discontinue if patient is unable to lose at least 5% of the body wt during the 1st 12 wk of therapy. Child Dose: <12 years: Safety and efficacy not established Contraindication: Chronic malabsorption syndrome. Cholestasis. Lactation Mode of Action: Orlistat is a reversible gastric and pancreatic lipase inhibitor. It exerts antiobesity effects by limiting the absorption of dietary fats through inhibition of triglyceride hydrolysis. It does not exert appetite suppressant effects. Precaution: Patient w/ history of hyperoxaluria or Ca oxalate nephrolithiasis. Monitoring Parameters Monitor BMI, diet, LFT, serum glucose (in patient w/ DM), thryroid function (in patient w/ thyroid disease). Lactation: Not recommended; not known if orlistat is distributed in breast milk Side Effect: 1-10% Oily spotting (5%) Frequency Not Defined Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort. Potentially Fatal: Anaphylaxis; angioedema. Interaction: May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.