Silimar 500 - Capsule Silymarin [Milk thistle] - 500mg 30 Capsule(s) / Box Neo Pharma Bangladesh Introduction: Silimar 500 is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Silimar 500 exhibits hepatoprotective and regenerative properties and is one of the most widely used natural compounds for the treatment of hepatic diseases worldwide, due to its antioxidant, anti-inflammatory, and antifibrotic activities. Silimar 500 also increases hepatic levels of glutathione by raising cysteine availability, while inhibiting its catabolism to taurine that may enhance the antioxidant defense in liver. Silimar 500 was found to oppose oxidative stress, and to slow the progression of hepatic fibrosis in alcohol-fed baboons. Uses of Silimar 500: Silimar 500 is used for the treatment of Jaundice,chronic inflammatory liver conditions, hepatic cirrhosis ,alcoholic liver damage. Side effects of Silimar 500: Mild digestive upset Allergic reactions How to use Silimar 500: Take Silimar 500 in the dose and duration as advised by your doctor. Take Silimar 500 orally with plenty of water. Do not chew, crush or break it. How Silimar 500 work: Different mechanisms of action of Silimar 500 are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as Silimar 500 has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of Silimar 500 is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp),... What if you forget to take Silimar 500: If you forget to take yourSilimar 500 , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time. Indication: It is used for the treatment and prevention of- Liver disease, (non-alcoholic & alcoholic) , Liver cirrhosis, (non-alcoholic & alcoholic) Infectious hepatitis, Drug-induced hepatitis, Liver disease secondary to diabetes mellitus, Toxicity of narcotics, Fatty liver, Jaundice. Administration: Administered only orally as advised by the physician. Adult Dose: 1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician. Child Dose: It should not be given to children without advice of physician. Uses for below 12 years recommended after discussion with registered physician. Renal Dose: It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor. Contraindication: Contraindicated in patient with a known hypersensitivity to silymarin. Mode of Action: Different mechanisms of action of silymarin are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as silymarin has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of silymarin is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake... Precaution: Over doses may mildly elevate blood pressure. Safety in young children or individuals with severe hepatic or renal disease is not known. Side Effect: Occasionally a mild laxative effect may observe. Well tolerated in the recommended dose. Pregnancy & Lactation Category Note: Therefore, if needed Silymarin should be taken with caution according to the physician’s advice. No established evidence is available about the use of Silymarin during pregnancy and lactation. Interaction: Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation. Storage Condition: Store in a cool & dry place, away from light & moisture. Keep out of reach of children.