Sentix 0.5 - Tablet Flupenthixol (flupentixol) - 0.5mg 10 Tablet(s) / Strip Eskayef Pharmaceuticals Ltd. Introduction: Sentix 0.5 is a prescription medicine used in the treatment of schizophrenia. It may also be used to treat depression and bipolar disorder. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Sentix 0.5 may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as... Uses of Sentix 0.5: Schizophrenia Side effects of Sentix 0.5: SleepinessOrthostatic hypotension (sudden lowering of blood pressure on standing)Dryness in mouthAbnormality of voluntary movementsWeight gainIncreased prolactin level in bloodUrinary retentionConstipationMuscle stiffnessTremor How to use Sentix 0.5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sentix 0.5 may be taken with or without food, but it is better to take it at a fixed time. How Sentix 0.5 works: Sentix 0.5 is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Indication: Depression, Schizophrenia, Psychoses Administration: May be taken with or without food. Adult Dose: Oral Psychoses Adult: Initially, 3-9 mg bid, adjusted according to response. Max: 18 mg daily. Elderly: Initial dose: ¼ or ½ of the usual initial dose. Oral Depression with or without anxiety Adult: Initially, 1 mg daily increased after 1 wk to 2 mg daily and then to a max of 3 mg daily, last dose should be given not later than 4 p.m. Doses >2 mg should be given in 2 divided doses. Discontinue treatment if there is no improvement within 1 wk of using the max dose. Elderly: Initially, 0.5 mg daily increased after 1 wk to 1... Contraindication: Hypersensitivity. Extremely excitable and overactive patients; mania; porphyria; coma; preexisting CNS depression; bone-marrow supression; phaeochromocytoma. Lactation. Mode of Action: Flupentixol is a thioxanthene antipsychotic that inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS. Precaution: Patients with convulsive disorders; advanced hepatic, renal, CV or resp disease; tasks requiring mental alertness; elderly (especially with dementia), and debilitated patients; neuroleptics with sedative effect must be withdrawn gradually; history of angle-closure glaucoma; urinary retention; prostatic hyperplasia; breast cancer, prolactin dependent tumours; parkinsonism; myasthenia gravis; pregnancy; Avoid direct sunlight. Side Effect: Rigidity, tremors, restlessness, tardive dyskinesia, insomnia, dryness of mouth, wt gain, sexual dysfunction, galactorrhoea and menstrual disturbances. Potentially Fatal: Neuroleptic malignant syndrome (hyperthermia, hypertonicity of skeletal muscles, unconsciousness and autonomic nervous system instability). Pregnancy Category Note: Pregnancy category: C Lactation: Drug enters breast milk; not recommended Interaction: May potentiate the adverse effects of drugs with antimuscarinic effects e.g. TCAs. Reduced efficacy of levodopa. Increases adverse extrapyramidal symptoms with dopamine antagonists (metoclopramide and prochlorperazine). Potentially Fatal: Potentiates CNS effects of alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Blocks antihypertensive effect of guanethidine.