SB-LosaK - Tablet Losartan Potassium - 50mg 1 Tablet(s) / Tablet Sunman-Birdem Pharma Ltd. Introduction: SB-LosaK is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. SB-LosaK can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most... Uses of SB-LosaK: Hypertension (high blood pressure)Heart failurePrevention of heart attack and stroke Side effects of SB-LosaK: DizzinessDecreased blood pressureHypoglycemia (low blood glucose level)Increased potassium level in bloodIncreased blood urea How to use SB-LosaK: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. SB-LosaK may be taken with or without food, but it is better to take it at a fixed time. How SB-LosaK works: SB-LosaK is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently. What if you forget to take SB-LosaK?: If you miss a dose of SB-LosaK, skip it and continue with your normal schedule. Do not double the dose. Indication: Diabetic nephropathy, Hypertension, Stroke risk reduction of hypertensive or LVH patients, Heart Failure, Hypertensive Patients with Left Ventricular Hypertrophy Administration: May be taken with or without food. Adult Dose: Oral Hypertension Adult: 50 mg once daily, may increase to 100 mg/day as single dose or in 2 divided doses if needed. Patients w/ intravascular volume depletion: Initially, 25 mg once daily. Diabetic nephropathy in Type 2 diabetes mellitus Adult: Initially, 50 mg once daily, may increase to 100 mg once daily depending on BP response. Heart failure, Hypertension and Left Ventricular Hypertrophy, Stroke risk reduction of hypertensive or LVH patients: Adult: Initially, 50 mg once daily. Hydrochlorothiazide 12.5 mg daily should be added and/or the dose of Losartan should be increased to 100 mg once daily followed by an... Child Dose: Hypertension 6 yr 20-50 kg: Initially, 0.7 mg/kg. Max: 50 mg/day; >50 kg: Initially, 1.4 mg/kg. Max: 100 mg/day. Renal Dose: Renal impairment: CrCl <20 ml/min: Initially 25 mg once daily. Contraindication: Losartan potassium is contraindicated in patients who are hypersensitive to the active ingredient or any component of the drug. Concomitant use w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min). Severe hepatic impairment. Pregnancy. Mode of Action: Losartan is an angiotensin II receptor antagonist. It selectively and competitively blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors. Precaution: Volume-depleted patients including patients on high-dose diuretics. Patients w/ bilateral renal artery stenosis , aortic or mitral stenosis. Renal and mild to moderate hepatic impairment. Lactation. Monitoring Parameters Monitor BP, electrolytes and renal function. Lactation: Unknown if excreted in milk; not recommended Side Effect: >10% Fatigue (14%),Hypoglycemia (14%),Anemia (14%),Urinary tract infection (UTI) (13%),Chest pain (12%),Weakness (14%),Diarrhea (2-15%),Cough; incidence higher in previous cough related to angiotensin-converting enzyme (ACE) inhibitor therapy (3-11%) 1-10% Upper respiratory tract infection (8%),Hypotension (7%),Dizziness (4%),Cellulitis (7%),Gastritis (5%),Nausea (2%) Frequency Not Defined Angioedema,Edema/swelling,Hypotension in hypovolemic or diuretic-using patients,Asthenia,Headache,Malaise,Nausea,Abdominal pain,Hyperkalemia,Back pain,Worsening renal failure Pregnancy Category Note: Pregnancy Categories C (first trimester) and D (second and third trimesters). Interaction: May decrease plasma levels / fluconazole and rifampicin. May increase serum lithium levels and toxicity. May antagonise hypotensive effect and increase risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes. Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).