SB-Eto 120 - Tablet Etoricoxib - 120mg 10 Tablet(s) / Strip Sunman-Birdem Pharma Ltd. Introduction: SB-Eto 120 is a pain relieving medicine. It is used for relieving moderate pain and swelling of joints associated with different forms of gout and arthritis. It is also used for short-term treatment of moderate pain after dental surgery in people 16 years of age and older. SB-Eto 120 can be taken with or without food. The dose depends on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer than recommended. The most common side effects of this... Uses of SB-Eto 120: Pain relief Side effects of SB-Eto 120: Stomach painDiarrhea How to use SB-Eto 120: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. SB-Eto 120 may be taken with or without food, but it is better to take it at a fixed time. How SB-Eto 120 works: SB-Eto 120 is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling). Indication: Rheumatoid arthritis, Osteoarthritis, Gout Administration: May be taken with or without food. Adult Dose: Oral Osteoarthritis Adult: 30 mg once daily, increased to 60 mg once daily if needed. Ankylosing spondylitis; Rheumatoid arthritis Adult: 90 mg once daily. Acute gout Adult: 120 mg once daily. Max duration: 8 days. Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily. Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily. Severe (Child-Pugh >10): Avoid. Child Dose: Child: <16 yr Contraindicated. Contraindication: Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr. Mode of Action: Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2. Precaution: Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy. Side Effect: GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity. Interaction: May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.