Sandom 10 - Tablet Domperidone - 10mg 10 Tablet(s) / Strip Synovia Pharma PLC. Introduction: Sandom 10 is a prescription medicine used in the treatment of indigestion, nausea and vomiting. It blocks the substance on the brain that triggers nausea or vomiting and it also increases the movement of food in the stomach, thereby improves digestion. Sandom 10 is taken before meals in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may... Uses of Sandom 10: IndigestionNauseaVomiting Side effects of Sandom 10: HeadacheDryness in mouthStomach painDiarrhea How to use Sandom 10: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sandom 10 is to be taken empty stomach. How Sandom 10 works: Sandom 10 is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach. What if you forget to take Sandom 10?: If you miss a dose of Sandom 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Gastritis, Lactation, Migraine, Nausea and vomiting, Gastroparesis, Non ulcer dyspepsia Administration: Should be taken on an empty stomach. Take 15-30 min before meals. Adult Dose: Oral Adults: Nausea and vomiting 10-20 mg 4-8 hrly. Max: 80 mg/day. Non ulcer dyspepsia 10 mg 3-4 times daily. Max: 20 mg 3-4 times daily. Last dose to be taken at bedtime. Migraine 20 mg 4 hrly. Max: 4 doses/24 hr. Rectal: Nausea and vomiting 60 mg twice daily. Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed. Child Dose: Oral Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily. Rectal Child: 15 kg: 30 mg bid; >12 yr >35 kg: 60 mg bid. Renal Dose: Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Reduce dosing to 1-2 times daily w/ prolonged treatment. Contraindication: Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone, chronic admin or routine prophylaxis of postoperative nausea and vomiting. Mode of Action: Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time. Precaution: Phaeochromocytoma; children<2 yr, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy and lactation. Side Effect: Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, skin rash, itch. Potentially Fatal: Convulsions, arrhythmias and cardiac arrest, dysrrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures; hypertensive crisis in patients with phaeochromocytoma. Interaction: May antagonise the hypoprolactinaemic effect of bromocriptine. May antagonise the prokinetic effect w/ opioid analgesics and antimuscarinics. Potentially Fatal: Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin or ritonavir) may increase serum domperidone levels and subsequently increasing the risk of QT prolongation.