Retapex - Ointment Retapamulin 1% Topical - 1% 1 10gm(s) / 10gm Incepta Pharmaceuticals Ltd. Introduction: Retapex is an antibiotic. It is used in the treatment of bacterial skin infections. It stops the growth of bacteria that cause infections and thus relieves your symptoms. Retapex is for external use only. You should use it in the dose and duration as advised by your doctor. The affected area should be clean and dry before application of the ointment. You must wash your hands thoroughly before and after applying this medicine. To avoid relapse, continue the use of this medicine even if symptoms begin to clear up. Do not cover the area being treated with airtight dressings such... Uses of Retapex: Bacterial skin infections Side effects of Retapex: Skin irritation How to use Retapex: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. How Retapex works: Retapex stops the growth of bacteria that cause infections. Indication: Impetigo, Bacterial skin infections Adult Dose: Topical/Cutaneous Impetigo; Bacterial skin infections due to meticillin-susceptible, Staphylococcus aureus and Streptococcus pyogenes Adult: As 1% ointment: Apply onto affected area bid for 5 days. Re-evaluate if there is no response after 3 days of treatment. Total treatment area: <100 cm2 total body surface area. Child Dose: Topical/Cutaneous Impetigo; Bacterial skin infections due to meticillin-susceptible, Staphylococcus aureus and Streptococcus pyogenes Child: As 1% ointment: >9 mth: Apply onto affected area bid for 5 days. Total treatment area: <2% of total body surface area. Contraindication: Hypersensitivity. Mode of Action: Retapamulin is a pleuromutilin antibacterial isolated from the fungus Clitopilus passeckerianus. It is a bacteriostatic agent that works by inhibiting biosynthesis of bacterial protein by binding at protein L3 on the ribosomal 50S subunit. It also inhibits peptidyl transfer and blocks P-site interactions at this site, thus preventing the formation of active 50S ribosomal subunits. Precaution: Discontinue use if skin irritation occurs. Prolonged use may result in fungal or bacterial superinfection. Re-evaluate if there is no response within 3 days. Children <9 mth. Pregnancy, lactation. Lactation: use caution Side Effect: 1-10% Application site irritation (2%) Headache, pyrexia, pruritus, eczema, diarrhoea. Interaction: Concurrent application w/ other topical products to the same skin area is not recommended.