Renxit - Tablet Flupenthixol + Melitracen - 500mcg+10mg 10 Tablet(s) / Strip Renata Limited Introduction: Renxit is a combination of two medicines used in the treatment of depression. This medicine helps by increasing the level of chemical messengers in the brain that have a calming effect on the brain and relax the nerves, thus treating your depression. Renxit may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it... Uses of Renxit: Depression Side effects of Renxit: ConstipationUrinary retentionWeight gainSleepinessOrthostatic hypotension (sudden lowering of blood pressure on standing)Increased heart rateIncreased prolactin level in bloodBlurred visionDryness in mouthMuscle stiffnessTremorRestlessness How to use Renxit: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Renxit may be taken with or without food, but it is better to take it at a fixed time. How Renxit works: Renxit is a combination of two medicines: Flupenthixol and Melitracen. Flupenthixol is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Melitracen is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. Indication: Depression, Anxiety, Apathy, Dysphoria Adult Dose: Adults: Usually 2 tablets daily; morning and noon. In severe cases the morning dose may be increased to 2 tablets. Elderly: 1 tablet in the morning. Maintenance dose: Usually 1 tablet in the morning. In cases of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended. Contraindication: The immediate recovery phase after myocardial infarction, Defects in bundle-branch conduction, Untreated narrow angle glaucoma, Acute alcohol, barbiturate and opiate intoxications, Flupentixol-Melitracen should not be given to patients who have received a MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics. Mode of Action: Flupentixol is a thioxanthene antipsychotic that inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS. Melitracen is a TCA with anxiolytic properties. Precaution: If previously the patient has been treated with tranquilizers with sedative effect these should be withdrawn gradually. Side Effect: In the recommended doses side effects are rare. These could be transient restlessness and insomnia. Interaction: May potentiate the adverse effects of drugs with antimuscarinic effects e.g. TCAs. Reduced efficacy of levodopa. Increases adverse extrapyramidal symptoms with dopamine antagonists (metoclopramide and prochlorperazine). Potentially Fatal: Potentiates CNS effects of alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Blocks antihypertensive effect of guanethidine. Additive toxicity with antimuscarinics, CNS depressants. Response to TCA may be accelerated with thyroid hormones; pressor effects of sympathomimetics may be enhanced; risk of serotonin syndrome when taken with other antidepressants. Antidiabetic dosage may need to be adjusted.