Recin - Eye/Ear Drops Gentamicin 0.3% E/E prep - 0.30% 1 10ml bot(s) / 10ml bot Reman Drug Laboratories Ltd. Introduction: Recin is an antibiotic instilled in the eye to treat bacterial infections of the eye (eg. conjunctivitis). Additionally, it may be instilled in the ear to treat bacterial infections of the ear (eg. otitis externa). Recin also helps to prevent an infection after eye/ear injury or surgery. It fights the infection by stopping the growth of bacteria. This helps to resolve your symptoms and cure the underlying infection. Follow your doctor's instructions precisely for administering this medicine in the eye/ear. Wait for at least 5 minutes before applying any other medication to the same eye/ear. It should be used regularly... Uses of Nicogenta Eye/Ear Drops: Bacterial eye / ear infections Side effects of Nicogenta Eye/Ear Drops: Limited data available How to use Nicogenta Eye/Ear Drops: This medicine is for external use only.Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye/ear without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid or ear. Wipe off extra liquid. How Nicogenta Eye/Ear Drops works: Recin is an antibiotic. It stops bacterial growth in the eye/ear by preventing synthesis of essential proteins required by bacteria to carry out vital functions. This treats your eye/ear infection. What if you forget to take Nicogenta Eye/Ear Drops?: If you miss a dose of Recin, please consult your doctor. Indication: Superficial ophthalmic infections, Otitis externa, Adult Dose: Ophthalmic Superficial ophthalmic infections Adult: As eye drops: Instill 1-2 drops into affected eye up to 6 times daily. For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled. As eye oint: Place a small amount into the conjunctival sac 2-3 times daily. Otic/Aural Otitis externa Adult: As ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night. Child Dose: Ophthalmic Superficial ophthalmic infections Child: As eye drops: Instill 1-2 drops into affected eye up to 6 times daily. For severe infections, initially, 1-2 drops every 15 min, reducing the frequency gradually as the infection is controlled. As eye oint: Place a small amount into the conjunctival sac 2-3 times daily. Otic/Aural Otitis externa Child: As ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night. Contraindication: History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum. Mode of Action: Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective. Precaution: Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions. Lactation: safety in nursing infants unknown Side Effect: Allergic contact dermatitis, Transient irritation, burning, stinging, Increased redness, lacrimation Interaction: Additive effect w/ other neurotoxic and/or nephrotoxic drugs including cephalosporins, methicillin, amphotericin B, ciclosporin, cisplatin, potent diuretics (e.g. ethacrynic acid, furosemide) and neuromuscular blocking agents (e.g. succinylcholine, tubocurarine). May potentiate the effect of anticoagulants (e.g. warfarin, phenindione). May antagonise the effect of neostigmine and pyridostigmine. Increased risk of hypocalcaemia w/ bisphosphonates. Increased risk of neuromuscular blockade w/ botulinum toxin. Indometacin may increase the plasma concentration of gentamicin in neonates.