Rebozen-40 DSR - capsule Rabeprazole + Domperidone - 40mg 10 Capsule(s) / Box Leeford Healthcare Ltd Introduction: Rebozen-40 DSR is a combination medicine used to treat gastroesophageal reflux disease (Acid reflux) and peptic ulcer disease by relieving the symptoms of acidity such as heartburn, stomach pain, or irritation. It also neutralizes the acid and promotes easy passage of gas to reduce stomach discomfort. Rebozen-40 DSR is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms... Uses of Rebozen-40 DSR: Gastroesophageal reflux disease (Acid reflux)Peptic ulcer disease Side effects of Rebozen-40 DSR: DiarrheaStomach painDryness in mouthHeadacheDizzinessFlatulenceWeaknessFlu-like symptoms How to use Rebozen-40 DSR: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rebozen-40 DSR is to be taken empty stomach. How Rebozen-40 DSR works: Rebozen-40 DSR is a combination of two medicines: Domperidone and Rabeprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Rabeprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn. Indication: Short-term treatment of GERD. Administration: Should be taken on an empty stomach: Take 15-30 min before meals. Swallow whole, do not chew/crush. Adult Dose: Adult & adolescent >12 yr 1 cap once daily for 4-8 wk. Contraindication: Hypersensitivity to substituted benzimidazoles. Prolactinoma, severe hepatic impairment, GI hemorrhage, mechanical obstruction or perforation. Mode of Action: Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase at the secretory surface of the gastric parietal cell. Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time. Precaution: Exclude gastric malignancy prior to treatment. Prolonged treatment. Pregnancy & lactation. Childn. Elderly. Side Effect: Asthenia, fever, allergic reaction, chills, malaise, substernal chest pain, neck rigidity, photosensitivity reaction. CV, GI, endocrine, hemic & lymphatic, metabolic & nutritional, musculoskeletal, CNS, resp, urogenital, skin & special senses disturbances. Interaction: Monitor for increase in INR & prothrombin time when given w/ warfarin, cyclosporine, ketoconazole, ritonavir, erythromycin.