PZes Vitamin E - capsule Vitamin E (Alpha-tocopherol) - 400mg 30 Capsule(s) / Box Meyer Indication: Cardiovascular disease, Male infertility, Diabetes, Obesity, Vitamin E deficiency, Peripheral neuropathy, Macular Degeneration Adult Dose: Oral Adult: Betterment of Cardiovascular health: 400 mg - 800 mg / day Deficiency syndrome in adults: 200 mg - 400 mg / day Thalassemia: 800 mg / day Sickle-cell anemia: 400 mg / day Betterment of Skin & Hair: 200 mg - 400 mg / day. Chronic cold in adults: 200 mg / day Child Dose: Oral Deficiency syndrome in children: 200 mg / day Contraindication: There is no absolute contraindication except known hypersensitivity to vitamin E. Mode of Action: Vitamin E plays a role in protecting red blood cells against hemolysis; has protective effects against free radicals on polyunsaturated fatty acids found in cell membranes; plays a role in preventing oxidation of vitamin A and C. Precaution: Vitamin E may enhance the anticoagulant activity of anticoagulant drugs. Side Effect: Fatigue,Headache,Flatulence,Diarrhea,Blurred vision,Necrotizing enterocolitis (infants),Increased serum creatinine,Increased risk of hemorrhagic stroke,Recent evidence suggests that Vitamin E may suppress action of other antioxidants Interaction: Colestyramine, colestipol, and orlistat may interfere with vitamin E absorption. High doses of vitamin E potentiates the anticoagulant action of warfarin. Large doses of vitamin E may impair response to iron supplementation.