Pycuron - Injection Pipecuronium bromide - 4mg/2ml 1 Injection(s) / Injection EDCL Introduction: Pycuron belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It is also used to facilitate emergency airway management in patients in intensive care. Pycuron is administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The medicine is generally well-tolerated with little or no side effects. However, it may cause injection site reactions (such as pain, redness, and swelling),... Uses of Pycuron: Skeletal mucle relaxation during surgery Side effects of Pycuron: Skin rashIncreased saliva productionInjection site reactions (pain, swelling, redness)High blood pressure How to use Pycuron: Your doctor or nurse will give you this medicine. Kindly do not self administer. How Pycuron works: Pycuron is a muscle relaxant. It works by relaxing the muscles during a surgical procedure by blocking the transmission of impulses from the nerves to the muscles. Indication: Muscle relaxant in general anaesthesia, Facilitate endotracheal intubation Adult Dose: Intravenous Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation Adult: Initial dose: 80-100 mcg/kg. Subsequent doses: 10-20 mcg/kg. Initial dose following suxamethonium admin or in patients at high risk: 50-60 mcg/kg. Initial dose for caesarean section: 35 mcg/kg. Contraindication: Hypersensitivity. Mode of Action: Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker. It does not have significant CV adverse effects or histamine-related effects. Precaution: Pulmonary disease, respiratory insufficiency, asthma, neuromuscular disease, dehydration, severely ill patients, hepatic or renal impairment. Doses in obese patients should be based on patient's ideal body weight. Pregnancy, lactation. Side Effect: Transient hypotension, bradycardia, reduced cardiac output. Potentially Fatal: Anaphylactic reactions and malignant hyperthermia. Interaction: Actions antagonised by cholinesterases and long term carbamazepine, phenytoin or corticosteroids usage. Enhanced block when used with drugs that have neuromuscular blocking activity such as lidocaine, quinidine, verapamil and aminoglycosides. Potentially Fatal: Effects enhanced by volatile inhalational anaesthetics, ketamine (IV), antiarrhythmics, antibacterials, K depleting diuretics, parenteral Mg salts.