Prozine - Tablet Promethazine Hydrochloride - 25mg 1 Tablet(s) / Tablet Zenith Pharmaceuticals Ltd. Introduction: Prozine used in the treatment of various allergic conditions like runny nose, sneezing, congestion, itching and watery eyes. It also treats nausea, vomiting and insomnia (difficulty in sleeping) in adults and used as a sedative (sleep causing) in children (for 5 years and above). Prozine should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for... Uses of Prozine: NauseaVomiting Side effects of Prozine: Dryness in mouthBlurred visionHeadacheDizziness How to use Prozine: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prozine may be taken with or without food, but it is better to take it at a fixed time. How Prozine works: Prozine is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Prozine works by blocking the action of histamine, thereby relieving these symptoms. It also works directly on several areas of the brain to prevent nausea/vomiting and help you feel more relaxed. What if you forget to take Prozine?: If you miss a dose of Prozine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Allergic conditions, Nausea and vomiting, Motion sickness, Insomnia Administration: May be taken with or without food. Adult Dose: Oral Allergic conditions Adult: As promethazine HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily. Prophylaxis of motion sickness Adult: As promethazine HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As promethazine teoclate: 25 mg given on the night or 1-2 hr before travelling. Short-term management of insomnia Adult: As promethazine HCl: 20-50 mg at night. Parenteral Allergic conditions; Sedation Adult: As promethazine HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not... Child Dose: Oral Allergic conditions Child: As promethazine HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses. Prophylaxis of motion sickness Child: As promethazine HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary. Short-term management of insomnia Child: As promethazine HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg. Parenteral Allergic conditions; Sedation Child: As promethazine HCl: 5-10 yr 6.25-12.5 mg by deep IM. Renal Dose: Renal impairment: Dose reduction may be required. Contraindication: Patients in coma or suffering from CNS depression of any cause. Childn <2 yr. SC and intra-arterial admin. Concurrent use w/ or w/in 14 days of MAOI use. Mode of Action: Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong alpha-adrenergic blocking effect. It competitively binds to H1-receptors. Precaution: Patient w/ asthma, bronchitis or bronchiectasis; severe coronary artery disease, narrow-angle glaucoma, epilepsy, bladder neck or pyloro-duodenal obstruction, Reye's syndrome, bone marrow depression, Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause marked drowsiness, if affected, do not drive or operate machinery. Avoid prolonged exposure to sunlight. Monitoring Parameters Monitor mental status; signs and symptoms of tissue injury (IV inj). Lactation: Not known whether drug crosses into breast milk; discontinue drug, or do not nurse Side Effect: Neuroleptic Malignant Syndrome (NMS); CV effects (e.g. bradycardia, tachycardia, transient HTN, hypotension; jaundice, blood dyscrasias, extrapyramidal effects; IV inj: Severe tissue injury (e.g. gangrene), pain and burning, paralysis, thrombophlebitis, severe spasm of distal vessels, necrosis. Sedation, Confusion, Disorientation, Blurred vision, Hallucinations, Dystonias, Catatonic states, Euphoria, Excitation, Impotence, Urinary retention Potentially Fatal: Resp depression and apnoea esp in childn. Interaction: Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids. Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval. Increased risk of extrapyramydal effects w/ MAOIs.