Propofol Lipuro - Injection Propofol - 10mg/ml 1 Injection(s) / Injection DBL Healthcare Introduction: Propofol Lipuro is a general anesthetic. It is used in major surgical procedures. It allows the procedures to be carried out without pain and distress. This injection is used in a hospital setting only. Propofol Lipuro is used in general anesthesia. It causes loss of consciousness which is reversible. It is administered under the supervision of a healthcare professional. The most common side effects include headache, vomiting, and nausea. This Propofol Lipuro is safe to use in pregnancy, breastfeeding mothers, patients of liver and kidney disease. Inform your doctor if you are on any medications or have any known allergy... Uses of Propofol Lipuro: General Anaesthesia Side effects of Propofol Lipuro: NauseaHeadacheVomitingLocal site painSlow heart rateDecreased blood pressure How to use Propofol Lipuro: Your doctor or nurse will give you this medicine. Kindly do not self-administer. How Propofol Lipuro works: Propofol Lipuro is a general anaesthetic. It works by causing reversible loss of consciousness. This allows surgical procedures to be carried out without pain and distress. Indication: General anaesthesia, Sedation Adult Dose: Intravenous Induction and maintenance of general anaesthesia Adult: Induction: 40 mg by inj or infusion every 10 sec. Usual dose: 1.5-2.5 mg/kg. Maintenance: 4-12 mg/kg/hr or intermittent bolus inj of 20-50 mg. Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 sec. Maintenance: 3-6 mg/kg/hr. Usual dose needed: 1-1.5 mg/kg. Sedation Adult: In diagnostic and surgical procedures: Initially, 6-9 mg/kg/hr by infusion given for 3-5 minutes or an alternative dose of 0.5-1 mg/kg by slow inj over 1-5 minutes. Maintenance: 1.5-4.5 mg/kg/hr infusion. Reduce maintenance dose by 20% for high-risk patients needing sedation. For... Child Dose: Intravenous Anesthesia Induction 3-16 years: 2.5-3.5 mg/kg IVP over 20-30 sec Maintenance 2 months to 16 years: 0.125-0.3 mg/kg/min IV Contraindication: Electroconvulsive therapy, obstetrics. Sedation in children <16 yr. Pregnancy, lactation. Mode of Action: Short-acting, lipophilic sedative/hypnotic; causes global CNS depression, presumably through agonist actions on GABAa receptors. Precaution: Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 yr. Lactation: Excreted in breast milk; effect on nursing infant not known Side Effect: >10% Hypotension (peds 17%; adults 3-26%),Apnea lasting 30-60 sec (peds 10%; adults 24%),Apnea lasting >60 sec (peds 5%; adults 12%),Movement (peds 17%; adults 3-10%),Injection site burning/stinging/pain (peds 10%; adults 18%) 1-10% Respiratory acidosis during weaning (3-10%),Hypertriglyceridemia (3-10%),Hypertension (peds 8%),Rash (peds 5%; adults 1-3%),Pruritus (1-3%),Arrhythmia (1-3%),Bradycardia (1-3%),Cardiac output decreased (1-3%; concurrent opioid use increases incidence).Tachycardia (1-3%) <1% Arterial hypotension,Anaphylaxis,Asystole,Bronchospasm,Cardiac arrest,Seizures,Opisthotic rxn,Pancreatitis,Pulmonary edema,Phlebitis,Thrombosis,Renal tubular toxicity Potentially Fatal: Apnoea, bradycardia, hypotension, convulsions; anaphylaxis. Interaction: Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants.