Presnor 20 - Tablet Olmesartan Medoxomil - 20mg 7 Tablet(s) / Strip DBL Pharmaceuticals Ltd. Introduction: Presnor 20 is a medicine used to treat high blood pressure and heart failure. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Presnor 20 can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the maximum benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is... Uses of Presnor 20: Hypertension (high blood pressure)Heart failurePrevention of heart attack and stroke Side effects of Presnor 20: CoughDiarrheaDizzinessFlu-like symptomsHeadacheIndigestionNauseaRunny noseSore throatStomach pain How to use Presnor 20: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Presnor 20 may be taken with or without food, but it is better to take it at a fixed time. How Presnor 20 works: Presnor 20 is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently. What if you forget to take Presnor 20?: If you miss a dose of Presnor 20, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Hypertension, Diabetic nephropathy, Adult Dose: Oral Hypertension Adult: Initial: 10-20 mg once daily may then be increased up to max 40 mg once daily if needed. Elderly: No dosage adjustment needed. Hepatic impairment: Moderate: Initial: 10 mg once daily may increase up to max 20 mg once daily. Child Dose: Oral Hypertension Child: 6-16 yr 35 kg: 20 mg once daily. Doses may be doubled once if necessary after 2 wk. dosage range: 20-40 mg/day Renal Dose: Renal impairment: Mild to moderate (CrCl: 20-60 mL/min): Max: 20 mg once daily. Contraindication: Pregnancy (2nd and 3rd trimesters); biliary obstruction. Mode of Action: Olmesartan is a selective and competitive angiotensin II Type 1 (AT1) receptor antagonist that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. As a result, olmesartan relaxes blood vessels, hence lowering BP and increases blood supply and oxygen to the heart. Precaution: Drugs that act on renin-angiotensin system can cause fetal injury and death when used in 2nd and 3rd trimesters of pregnancy. Olmesartan medoxomil should be discontinued as soon as possible once pregnancy is detected. Symptomatic hypotension may occur in patients who are volume- and/or salt-depleted. May be associated with oliguria, progressive azotaemia, and acute renal failure (rare). Patients with bilateral or unilateral renal artery stenosis may have increased risk of severe hypotension and renal insufficiency. Caution in renal impairment; monitor serum creatinine and potassium levels periodically. Avoid use in severe renal impairment (CrCl< 20 mL/min) and severe hepatic impairment. Caution... Side Effect: 1-10% Dizziness,Headache,Fatigue,Diarrhea,Hyperglycemia,Hypertriglyceridemia,Back pain,Bronchitis,Inflicted injury,Flulike symptoms,Pharyngitis,Rhinitis,Sinusitis,Upper respiratory tract infection (URTI) Frequency Not Defined (selected) Anaphylactic reaction,Angioedema,Facial edema,Rhabdomyolysis,Hyperkalemia,Tachycardia,Hypercholesterolemia,Gastroenteritis,Hyperlipidemia Potentially Fatal: Acute renal failure. Pregnancy Category Note: Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D Interaction: Increased risk of hyperkalaemia w/ ACE inhibitors, K-sparing diuretics, K salts or K supplements and drugs that may increase serum K (e.g. ciclosporin, eplerenone). May potentiate BP lowering effects w/ other antihypertensives. May decrease glomerular filtration w/ NSAIDs which can cause acute renal failure. May increase serum concentrations and toxicity of lithium.