Prazopress ER 2.5 - Tablet Prazosin Hydrochloride - 2.5mg 10 Tablet(s) / Strip Unimed Unihealth Pharmaceuticals Ltd. Introduction: Prazopress ER 2.5 belongs to a class of medicines called as alpha-blocker. It is used to treat high blood pressure and lower your risk of having a heart attack or stroke. It may also be used to treat heart failure and mild enlargement of the prostate gland in men. Prazopress ER 2.5 may be prescribed alone or in combination with other medicines. It can be taken with or without food. The dose will depend on your condition and how you respond to the medicine. Follow the advice of your doctor on what is right for you. You need to use... Uses of Prazopress ER 2.5: Hypertension (high blood pressure) Side effects of Prazopress ER 2.5: DizzinessHeadacheDrowsinessWeaknessLow energyPalpitationsNausea How to use Prazopress ER 2.5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prazopress ER 2.5 may be taken with or without food, but it is better to take it at a fixed time. How Prazopress ER 2.5 works: Prazopress ER 2.5 is an alpha blocker. It lowers blood pressure by relaxing blood vessels so that blood can flow more easily through the body. What if you forget to take Prazopress ER 2.5?: If you miss a dose of Prazopress ER 2.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Hypertension, Benign prostatic hyperplasia, Raynaud's syndrome Administration: May be taken with or without food. Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or w/o meals. Adult Dose: Oral Hypertension Conventional Tablet: Adult: Initially, 0.5 mg bid or tid for 3-7 days, increased to 1 mg bid or tid for the next 3-7 days. Thereafter, the daily dose should be increased gradually as determined by the patient’s response to the blood pressure lowering effect. Most patients are likely to be maintained on a dosage regimen of Prazosin alone of up to 15 mg daily in divided doses. Max: 20 mg/day in divided doses.Dosage should be individualized depending on patient tolerance and response. Extended Release Tablet: Dosage should be individualized depending on patient tolerance and response. Adult: Initially, Prazosin... Renal Dose: Renal impairment: Dose reduction needed. Contraindication: Congestive heart failure due to mechanical obstruction. Hypersensitivity. Pregnancy. Mode of Action: Prazosin competitively blocks postsynaptic alpha1-adrenoceptors of veins and arterioles causing vasodilation, reduction in BP and total peripheral resistance usually w/o reflex tachycardia. Precaution: Prostate cancer should be ruled out before starting therapy. Patients w/ history of micturition syncope, angina pectoris. Treatment of heart failure due to mechanical obstruction (e.g. aortic or mitral valve stenosis, pulmonary embolism and restrictive pericardial disease). During cataract surgery, Intraoperative Floppy Iris Syndrome (IFIS) may occur. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. A low starting dose is given in the evening to lessen the risk of collapse. Hypotensive effects may be exaggerated by exercise and heat. Monitoring Parameters Monitor renal function. Careful monitoring of BP during initial... Side Effect: 1-10% Dizziness (10%),Drowsiness (8%),Headache (8%),Weakness (7%),Asthenia (6.5%),Nausea (5%),Palpitation (5%) Frequency Not Defined (Selected) Edema,Orthostatic hypotension,Syncope,Fever,Rash,Abdominal discomfort/pain,Diarrhea,Vomiting,Abnormal liver function tests,Impotence,Pancreatitis,Urinary incontinence Potentially Fatal: Rarely, hypotension may be life-threatening. Interaction: Hypotensive effects may be enhanced w/ diuretics and other antihypertensives. Increased risk of 1st dose hypotension w/ ?-blockers or Ca channel blockers. Concomitant admin w/ phosphodiesterase type 5 (PDE5) inhibitors (e.g. sildenafil) may result in additive hypotensive effects and symptomatic hypotension.