Picon Lotion - lotion Pimecrolimus 1% Topical - 1% w/w 1 50ml bot(s) / 50ml bot Era Health Care Introduction: Picon Lotion is used to treat eczema (atopic dermatitis). It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis. Picon Lotion is used for external use. It should be used 2-4 times a day on the affected area or use it as suggested by the doctor. It should be applied slowly and evenly to the skin until it is rubbed in. You should not use it too often and you should not cover the treated area with a bandage or plaster. You... Uses of Picon Lotion: Atopic dermatitis Side effects of Picon Lotion: Application site reactions (burning, irritation, itching and redness) How to use Picon Lotion: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. How Picon Lotion works: Picon Lotion is an immunosuppressant. It works by suppressing your body’s immune response. Indication: Atopic dermatitis, Eczema Adult Dose: Topical/Cutaneous Atopic dermatitis Adult: As 1% cream: Apply a thin layer onto the affected areas bid. Stop treatment if there is no improvement after 6 wk or if there is worsening of eczema. Hepatic impairment: Dosage reduction is necessary. Child Dose: Topical/Cutaneous Atopic dermatitis Child: >2 yr: Apply a thin layer of 1% cream onto the affected areas bid. Stop treatment if there is no improvement after 6 wk or if there is worsening of eczema. Hepatic impairment: Dosage reduction is necessary. Renal Dose: Renal impairment: Dosage reduction is necessary. Contraindication: Hypersensitivity; children <2 yr; immunocompromised patients. Patients with Netherton's syndrome. Mode of Action: Pimecrolimus is a macrolactam and is a derivative of ascomycin. It is an immunosuppressant which inhibits the activation of T-cells and prevents the release of inflammatory mediators from mast cells. It is used for the short term or intermittent long term treatment for mild to moderate atopic eczema. Precaution: Avoid use in areas affected by active, cutaneous viral infections. Avoid contact with the eyes and mucous membranes. Immunosuppression may increase risk of lymphoma and other malignancies. Limit exposure to sunlight or other UV light. Mild to moderate sensation of warmth and/or burning may occur at the treatment site within 1-5 days of initiation. Safety of usage beyond 1 yr is not established. Renal or hepatic impairment. Monitor renal, hepatic, cardiac and visual functions, BP, serum glucose and electrolytes regularly. Pregnancy, lactation. Lactation: not known whether distributed in breast milk; may cause unwanted effects in nursing babies Side Effect: >10% Burning sensation (2-26%),Headache (7-25%),Fever (1-13%),Nasopharyngitis (8-27%),Cough (2-16%),Bronchitis (<11%),Upper respiratory tract infection (4-19%) <1% Basal cell carcinoma of skin,Malignant melanoma,Squamous cell carcinoma,Malignant lymphoma,Septic arthritis,Skin discoloration,Eczema,Flushing,Ocular irritation Frequency Not Defined Skin infection,Rash,Application site pain,Paraesthesia,Desquamation,Dryness Interaction: Inhibitors of cytochrome P450 3A4 isoenzyme in patients with widespread and/or erythrodermic disease. Potentially Fatal: Increased risk of infections when used with live vaccines.