Phylopen 250 - Capsule Flucloxacillin - 250mg 10 Capsule(s) / Strip Square Pharmaceuticals PLC. Introduction: Phylopen 250 is an antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, skin and soft tissue, bones and joints and blood. Phylopen 250 is a penicillin-type of antibiotic, which mainly fights and stops the growth of the gram-positive type of bacteria. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. This medicine should be used regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do... Uses of Phylopen 250: Bacterial infections Side effects of Phylopen 250: NauseaVomitingDiarrheaAllergic reactionInjection site reactions (pain, swelling, redness) How to use Phylopen 250: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. How Phylopen 250 works: Phylopen 250 is an antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is needed for them to survive. What if you forget to take Phylopen 250?: If you miss a dose of Phylopen 250, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Pneumonia, Burns, Meningitis, Endocarditis, Sinusitis, Septicaemia, Tonsillitis, Surgical Prophylaxis, Staphylococcal skin infections, Boils, Osteomyelitis, Enteritis, Wounds, Abscesses, Infected eczema, Infected acne Administration: Should be taken on an empty stomach. Take on an empty stomach ½-1 hr before meals. Reconstitution: Dissolve 250-500 mg in 5-10 mL water for inj or 1 g in 15-20 mL water for inj. For IV infusion, further dilute in suitable IV fluids (e.g. water for inj, NaCl 0.9%, glucose 5%, NaCl 0.18% w/ glucose 4%). Adult Dose: Adults (including elderly patients): Oral: 250-500mg 3-4 times a day. Intravenous IV 0.25-1 g 4 times/day, may double in severe cases. Up to 8 g/day in 3-4 divided doses may be given for osteomyelitis. Up to 8 g/day in 4 divided doses for endocarditis in patients weighing 85 kg. Child Dose: Children have been given doses of 12.5-25 mg/kg body weight 4 times a day. Intravenous 2-10 years: Half of adult dose Under 2 years: One fourth of adult dose Renal Dose: Renal impairment: CrCl (ml/min) <10 Dosage adjustment may be necessary. Contraindication: Hypersensitivity to penicillins. Porphyria. Mode of Action: Flucloxacillin inhibits the 3rd and last step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. It is active against penicillinase-producing and non-penicillinase-producing staphylococci. Precaution: Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route; elderly. Hepatic impairment. Side Effect: Hypersensitivity reactions including urticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis; hepatitis, cholestatic jaundice; agranulocytosis; phlebitis (IV infusion). Potentially Fatal: Anaphylaxis. Stevens-Johnson syndrome Interaction: May increase the risk of methotrexate toxicity. May decrease the efficacy of oestrogen-containing OC. Enhanced plasma concentrations w/ probenecid. Bacteriostatic drugs (e.g. chloramphenicol, tetracycline) may interfere w/ the bactericidal effect of flucloxacillin. May prolong bleeding time in patients on oral anticoagulants.