Pediphen - Syrup Diphenhydramine Hydrochloride - 10mg/5ml 1 100ml bot(s) / 100ml bot Somatec Pharmaceuticals Ltd. Introduction: Pediphen is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching and other symptoms of allergies and common cold. It is also used to suppress coughs, to treat motion sickness and to induce sleep. Pediphen should be taken before a meal or at bedtime, but take it at the same time every day to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take... Uses of Pediphen: Motion sicknessInsomniaNasal allergy symptoms Side effects of Pediphen: DizzinessDrowsinessDryness in mouth How to use Pediphen: Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Pediphen may be taken with or without food, but it is better to take it at a fixed time. How Pediphen works: Pediphen is an antihistaminic medication. It blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions. What if you forget to take Pediphen?: If you miss a dose of Pediphen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Allergic rhinitis, Allergic conditions, Motion sickness, Common cold, Insomnia, Extrapyramidal symptoms Administration: May be taken with or without food. Adult Dose: Oral Allergic conditions; Treatment and prophylaxis of motion sickness Adult: 25-50 mg 3-4 times daily. For prevention of motion sickness, admin 30 min before exposure to motion. Max: 300 mg daily. Parkinson's disease Adult: Initially, 25 mg tid, may increase to 50 mg 4 times daily if necessary. Short-term management of insomnia Adult: 50 mg 30 min before bedtime as needed. Hepatic impairment: No dosage adjustment needed. Child Dose: Allergic Reaction 2-6 years: 6.25 mg q4-6hr; not to exceed 37.5 mg/day 6-12 years: 12.5-25 mg PO q4-6hr; not to exceed 150 mg/day >12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day Occasional Insomnia >12 years: 50 mg PO 30 minutes before bedtime Cough 12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day Motion Sickness Administer 30 min before motion 12.5-25 mg PO q6-8hr or 150 mg/m² ; not to exceed 300 mg/day Renal Dose: Renal impairment: No dosage adjustment needed. Contraindication: Hypersensitivity ; neonates, lactation. Mode of Action: Diphenhydramine blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also causes sedation and has some anticholinergic action. Precaution: Epilepsy; elderly; performing tasks which require mental alertness; angle-closure glaucoma; pyroduodenal obstruction; urinary tract obstruction; hyperthyroidism; raised intraocular pressure; CV disease; acute asthma; pregnancy. Lactation: Drug enters breast milk; contraindicated Side Effect: Chest tightness, extrasystoles, hypotension, palpitations, tachycardia; ataxia, chills, confusion, dizziness, drowsiness, euphoria, excitement, fatigue, headache, insomnia, irritability, nervousness, neuritis, paraesthesia, paradoxical excitation, restlessness, sedation, seizure, vertigo; diaphoresis; menstrual disease; GI disturbances (e.g. anorexia, constipation, diarrhoea); difficulty in micturition, urinary frequency, urinary retention; agranulocytosis, haemolytic anaemia, thrombocytopenia; anaphylactic shock; tremor; blurred vision, diplopia; acute labyrinthitis, tinnitus; constriction of pharynx, nasal congestion, thickening of bronchial secretions, wheezing; Pregnancy Category Note: Pregnancy category: B Lactation: Drug enters breast milk; contraindicated Interaction: Masks ototoxicity produced by aminoglycosides. Increases gastric degradation of levodopa and decreases its absorption by reduction of gastric emptying. Antagonises therapeutic effects of cholinergic agents e.g. tacrine, donezepil and neuroleptics. Valerian, St. John's wort, Kava Kava and gotu kola may increase CNS depression. Potentially Fatal: Potentiates CNS depression with alcohol, barbiturates, analgesics, sedatives and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and TCAs.