Parotin 10 - Tablet Paroxetine Hydrochloride - 10mg 10 Tablet(s) / Strip ACI Limited Introduction: Parotin 10 is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is widely prescribed to treat depression and anxiety-related conditions like panic disorder, obsessive-compulsive disorder, and post traumatic stress disorder (PTSD). Parotin 10 helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and... Uses of Parotin 10: DepressionObsessive-compulsive disorderPost traumatic stress disorderPanic disorderAnxiety Side effects of Parotin 10: Delayed ejaculationLow sexual desireNauseaTremorConfusionDizzinessDryness in mouthErectile dysfunctionFatigueIncreased sweatingInsomnia (difficulty in sleeping)Loss of appetiteNervousnessSleepiness How to use Parotin 10: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Parotin 10 may be taken with or without food, but it is better to take it at a fixed time. How Parotin 10 works: Parotin 10 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, panic disorder, anxiety and obsessive-compulsive disorder. Indication: Depression, Anxiety, Panic disorder, Obsessive-compulsive disorder, Posttraumatic stress disorder, Social anxiety disorder, Premenstrual dysmorphic disorder Administration: May be taken with or without food. May be taken w/ meals to minimise GI upset. Adult Dose: Oral Depression, Anxiety, Posttraumatic stress disorder Adult: 20 mg daily, increase gradually, if necessary, by 10-mg increments wkly; max: 50 mg/day. Obsessive compulsive disorder, Social anxiety disorder Adult: Initially, 20 mg daily, increase wkly in 10-mg increments. Maintenance: 40-60 mg daily. Panic disorder with or without agoraphobia Adult: Initially, 10 mg daily, increase wkly in 10-mg increments according to clinical response. Maintenance: 40-60 mg daily. Elderly: Initially, 10 mg daily, increase if needed by 10 mg/day at 1 wk intervals; max: 40 mg daily. Hepatic impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary. Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary. Contraindication: Use with or within 14 days of MAOIs; concurrent use with thioridazine or pimozide. Mode of Action: Paroxetine selectively inhibits the reuptake of serotonin. It has limited direct action at other neurotransmitter sites including muscarinic receptors. Precaution: Epilepsy, glaucoma, history of mania, cardiac disease, DM, history of bleeding disorders, on drugs with increased risk of bleeding; renal and hepatic impairment; patients receiving electroconvulsive therapy; achlorhydria or high gastric pH (reduced absorption of oral suspension). Pregnancy and lactation. The risk of suicidal behaviour may be higher in young adults, closely monitor. May impair ability to drive or perform tasks. Avoid abrupt withdrawal. Lactation Excreted in breast milk; use caution (AAP states effect on nursing infants is unknown but may be of concern) Side Effect: >10% (Based on 40 mg Dose) Nausea (15-24%),Insomnia (11-24%),Dry mouth (9-18%),Headache (17%),Asthenia (10-15%),Constipation (10-15%),Diarrhea (9-12%),Dizziness (6-14%),Ejaculation disorder (10-15%),Tremor (4-11%), 1-10% (Based on 40 mg Dose) Anxiety (5-10%),Blurred vision (5-10%),Decreased appetite (5-10%),Impotence (2-9%),Nervousness (2-5%),Paresthesia (2-5%),Hypomania (0.3 to 2.2%) Frequency Not Defined (Based on 40 mg Dose) Hypertension,Tachycardia,Emotional lability,Pruritus,Weight gain,Arthralgia,Tinnitus.Vertigo.Angle clossure glaucoma Serious Depression exacerbation,Mania (rare),Serotonin syndrome,Suicidal thoughts (rare),Suicide (rare),Seizure (rare),Toxic epidermal necrolysis,Hyponatremia (rare),Bleeding, abnormal (rare).Acute hepatitis (rare).Stevens-Johnson Syndrome Interaction: Levels/effects inhibited by cyproheptadine, phenytoin. Levels/effects increased by carbamazepine, cimetidine, CYP2D6 inhibitors (e.g. chlorpromazine, delavirdine, fluoxetine, miconazole, pergolide, quinidine, quinine, ritonavir, ropinirole). Increases levels/effects of atomoxetine, carvedilol, clozapine, CYP2B6 substrates (e.g. bupropion, promethazine, propofol, selegiline, sertraline), CYP2D6 substrates (e.g. amphetamines, selected beta-blockers, dextromethorphan, fluoxetine, lidocaine, mirtazapine, nefazodone, risperidone, ritonavir, thioridazine, TCAs, venlafaxine), duloxetine, galantamine, mexilitine, pimozide, procyclidine, propafenone. Decreases levels/effects of CYP2D6 prodrug substrates (e.g. codeine, hydrocodone, oxycodone, tramadol). Inhibits the metabolism of dextromethorphan, haloperidol, thioridazine. Enhances bradycardic effect of beta-blockers. Enhances toxic effects of other CNS depressants. Increased risk of serotonin syndrome with amphetamines, SSRIs, meperidine, nefazodone, trazodone, serotonin...