Ofloxacin-POS - eye_drop Ofloxacin 0.3% E/E drops - 3mg/ml 1 5ml drop(s) / 5ml drop ZAS Corporation Introduction: Ofloxacin-POS is an antibiotic, used in the treatment of bacterial infections of the eye. It relieves the symptoms of the infection by stopping the further growth of the causative microorganisms. Ofloxacin-POS is for external use only. Take it in the dose and duration as advised by your doctor. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. Avoid skipping any doses and finish the full course of treatment even if you feel better. It may cause eye discomfort, immediately following application. However, these... Uses of Ofloxacin-POS: Bacterial eye infections Side effects of Ofloxacin-POS: Eye discomfort How to use Ofloxacin-POS: This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. How Ofloxacin-POS works: Ofloxacin-POS is an antibiotic. It treats bacterial eye infections by preventing the bacteria from dividing and repairing. It does so stopping the action of a bacterial enzyme called DNA-gyrase. What if you forget to take Ofloxacin-POS?: If you miss a dose of Ofloxacin-POS, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Bacterial Conjunctivitis, Otic infections, Bacterial corneal ulcer Adult Dose: Ophthalmic Bacterial Conjunctivitis ; Keratoconjunctivitis Adult: Instill 1-2 drops in the affected eye(s) every 2-4 hr for the 1st 2 days, then 4 times daily. Max duration: 10 days. Corneal Ulcer Days 1-2: 1-2 drops q30min while awake Days 3-7: 1-2 drops q1hr while awake Days 7-9: 1-2 drops 4 times daily until clinical cure Otic/Aural Chronic Suppurative Otitis Media With Perforated Tympanic Membranes Adult: Instill 10 drops into the canal of the affected ear(s) bid for 14 days. Lie w/ the affected ear upwards for 5 min; pump the targus of the ear 4 times by pushing inward to... Child Dose: Ophthalmic Bacterial Conjunctivitis ; Keratoconjunctivitis Child>1 year: Instill 1-2 drops in the affected eye(s) every 2-4 hr for the 1st 2 days, then 4 times daily. Max duration: 10 days. Corneal Ulcer Child >1 year Days 1-2: 1-2 drops q30min while awake Days 3-7: 1-2 drops q1hr while awake Days 7-9: 1-2 drops 4 times daily until clinical cure Otic/Aural Chronic Suppurative Otitis Media With Perforated Tympanic Membranes Child >12 years: Instill 10 drops into the canal of the affected ear(s) bid for 14 days. Lie w/ the affected ear upwards for 5 min; pump the targus of the ear... Contraindication: Patients with a history of hypersensitivity to ofloxacin, to other quinolones, or to any of the components in this medication. Mode of Action: Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms. Precaution: As with other anti-infective preparations, prolonged use may result in over-growth of nonsusceptible organisms, including fungi. If the infection is not improved after one week, cultures should be obtained to guide further treatment. If otorrhea persists after a full course of therapy, or if two or more episodes of otorrhea occur within six months, further evaluation is recommended to exclude an underlying condition such as cholesteatoma, foreign body, or a tumor. The systemic administration of quinolones, including ofloxacin at doses much higher than given or absorbed by the otic route, has led to lesions or erosions of the cartilage in... Side Effect: Ophthalmic: Transient ocular burning or discomfort following instillation of the solution,Conjunctival hyperemia,Chemical conjunctivitis/keratitis,Foreign body sensation,Blurred vision,Periocular/facial edema,Eye pain,Photophobia,Pruritus,Stinging,Tearing,Dryness,Hemorrhagic conjunctivitis with palpebral edema (rare). Otic/Aural >10% Application site reaction (1-17%) 1-10% Taste perversion (7%),Pruritus (4%),Dizziness (1%),Earache (1%),Paresthesia (1%),Rash (1%),Vertigo (1%) <1% Otorrhagia,Tinnitus,Transient hearing loss,Tremor,Xerostomia,Diarrhea Interaction: Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.