Ocubac - Eye/Ear Drops Chloramphenicol 0.5% Eye drops - 0.50% 1 10ml drop(s) / 10ml drop Apex Pharma Ltd. Introduction: Ocubac is an antibiotic that fights bacteria. It is used to treat infections of the eye caused by bacteria. It works by killing the bacteria that cause these problems. Ocubac helps to improve your symptoms and cure the underlying infection. Follow your doctor's instructions precisely for administering this medicine in the eye. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. It is effective... Uses of Ocubac: Bacterial eye infections Side effects of Ocubac: Stinging in the eyesBlurred vision How to use Ocubac: This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. How Ocubac works: Ocubac is an antibiotic which stops the growth of bacteria that cause eye infections. It does so by preventing synthesis of essential proteins required by bacteria to carry out vital functions. This does not directly kill the bacteria, but prevents them from increasing in numbers, and eventually clears up the eye infection. Indication: Bacterial Conjunctivitis Adult Dose: Ophthalmic Ocular infections Adult: Instill 1 drop every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing. Reduce dose once symptoms are controlled or apply a 1% ointment 3-4 times daily. Hepatic impairment: Dose reduction may be required. Renal Dose: Renal impairment: Dose reduction may be required. Contraindication: History of hypersensitivity or toxic reaction to the drug; Herpes simplex and other virul conditions of the eye or ear, mycosis. Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae. Precaution: Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur. Side Effect: Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Interaction: Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.