Normens 5 - Tablet Norethisterone - 5mg 10 Tablet(s) / Strip Renata Limited Introduction: Normens 5 is used to treat various menstrual problems including painful, heavy, or irregular periods, premenstrual syndrome (PMS) and a condition called endometriosis. It is a man-made version of the natural female sex hormone progesterone. Normens 5 may be taken with or without food, but it is better to take it at the same time each day. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need so as to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this... Uses of Normens 5: Pain during menstruationEndometriosisHeavy menstrual bleeding Side effects of Normens 5: HeadacheDizzinessBreast tendernessNauseaVaginal spottingVomitingAbdominal cramp How to use Normens 5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Normens 5 may be taken with or without food, but it is better to take it at a fixed time. How Normens 5 works: Normens 5 is a synthetic progestin. It works by mimicking the effects of natural progesterone (female hormone). It helps in regulating the growth and shedding of the womb lining, thereby treating menstrual irregularities. Indication: Breast cancer, Metropathia haemorrhagica (dysfunctional uterine bleeding), Premenstrual syndrome, Contraception, Endometriosis, Menorrhagia, Menopausal HRT Administration: May be taken with or without food. Adult Dose: Oral Adult Abnormal bleeding – 1 tablet three times a day for 10 days. Bleeding usually stops within 1-3 days. A period usually starts 2-4 days after stopping treatment. Prevention of abnormal bleeding – 1 tablet twice a day from the 19th - 26th day of the cycle. Premenstrual Syndrome - 2 to 3 tablets a day from the 19th - 26th day of the cycle. You will normally be treated for several months. Delaying a period - 1 tablet three times a day starting three days before the expected beginning of the period. Your period should occur 2-3 days... Contraindication: Severe hepatic dysfunction; undiagnosed vaginal bleeding; porphyria; pregnancy; previous idiopathic or current thromboembolism; thromboembolic disease; DVT. Mode of Action: Norethisterone has typical effects of a progestogen and converts the endometrium from the proliferative to the secretory phase. It may also have some oestrogenic, anabolic and androgenic activities, but these may not be significant. Norethisterone delays onset of periods and controls abnormal uterine bleeding. It also has contraceptive effects due to negative feedback inhibition of pituitary gonadotropin thus preventing ovulation. Precaution: Hypertension; CVS disease; hepatic impairment; epilepsy; lactation; new onset of migraine-type headache; asthma; renal impairment; history of clinical depression. Side Effect: Mental depression, cholestatic jaundice, porphyria, epilepsy, migraine, headache, breast discomfort, dizziness, nausea and vomiting, changes in libido, appetite and weight, breakthrough bleeding, changes in menstrual flow, amenorrhoea, oedema, rash, melasma or cholasma, acne, urticaria, abnormal LFTs, moodswings, insomnia, thrombotic and thromoembolic events, optic neuritis, altered lipid profile. Interaction: Concentration may be reduced by CYP450 inducers (e.g. phenobarbital, phenytoin, carbamazepine, rifampicin, rifabutin, nevirapine, efavirenz, tetracyclines, ampicillin, oxacillin, co-trimoxazole) and ritonavir, nelfinavir (usually inhibitors of CYP450 but have inducing properties when used with steroid hormones). May cause additive fluid retention with NSAIDs, vasodilators. Adjustment in antidiabetic, thyroid hormone and anticoagulant therapy may be required. Potentially Fatal: May increase ciclosporin concentration.