Nexcital 5 - Tablet Escitalopram - 5mg 10 Tablet(s) / Strip Unimed Unihealth Pharmaceuticals Ltd. Introduction: Nexcital 5 is widely prescribed to treat depression and other mental health conditions like anxiety, panic disorder, and obsessive-compulsive disorder. It is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). Nexcital 5 helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually. Do not... Uses of Nexcital 5: DepressionAnxietyPanic disorderObsessive-compulsive disorder Side effects of Nexcital 5: Anorgasmia (decreased orgasm) in womenDecreased libidoDelayed ejaculationFatigueIncreased sweatingInsomnia (difficulty in sleeping)NauseaSleepiness How to use Nexcital 5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nexcital 5 may be taken with or without food, but it is better to take it at a fixed time. How Nexcital 5 works: Nexcital 5 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of anxiety, panic attacks and obsessive-compulsive disorders. What if you forget to take Nexcital 5?: If you miss a dose of Nexcital 5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Major depressive disorder, Depression, Panic disorder, Obsessive compulsive disorder, Anxiety disorder Administration: May be taken with or without food. Adult Dose: Oral Anxiety; Depression; Obsessive compulsive disorder Adult: 10 mg once daily, increased after at least a wk if needed. Max: 20 mg once daily. Panic disorder with or without agoraphobia Adult: Initially, 5 mg once daily, increased after a wk to 10 mg once daily. Max: 20 mg daily. Elderly: Half the adult dose. Hepatic impairment: Mild to moderate: Initially, 5 mg daily, increased to 10 mg daily after 2 wk if needed. Severe: More careful dose titration needed. Child Dose: Major Depressive Disorder 12 years: 10 mg PO qDay; may increase dose after at least 3 weeks; not to exceed 20 mg/day Contraindication: Concomitant use with or within 2 wk of MAOI withdrawal. Mode of Action: Escitalopram selectively inhibits CNS neuronal re-uptake of serotonin (5-HT) and potentiates serotonergic activity. It has minimal effects on norepinephrine and dopamine neuronal re-uptake. Precaution: History of mania or seizure disorders; work requiring mental alertness; renal and hepatic impairment; pregnancy, lactation; withdraw gradually. Lactation Excreted in breast milk; consider risk/benefit ratio Side Effect: >10% Headache (24%),Nausea (18%),Ejaculation disorder (9-14%),Somnolence (4-13%),Insomnia (7-12%) 1-10% Xerostomia (4-9%),Constipation (3-6%),Fatigue (2-8%),Libido decrease (3-7%),Anorgasmia (2-6%),Flatulence (2%),Toothache (2%),Weight gain (1%),Menstrual disorder (2%),Neck/shoulder pain (3%),Rhinitis (5%),Flu-like syndrome (5%),Ejaculation disorder (9-14%) <1% Arthralgia,Abdominal pain,Abnormal bleeding,Abnormal dreams,Allergy,Blurred vision,Bronchitis,Chest pain,Constipation,Decreased appetite,Decreased concentration,Disrupts platelets/hemostasis,Dizziness,Dyspepsia,Fever,Heartburn,Hot flashes,Impotence,Irritability,Jaw stiffness,Lethargy,Lightheadedness,Menstrual disorder,Hypertension,Palpitations,Migraine,Myalgia,Paresthesia,Rash,Sweating,Tinnitus,Tremor,Urinary frequency,Urinary tract infection,Vertigo,Vomiting,Yawning Pregnancy Category Note: Pregnancy There are no adequate and well-controlled studies in pregnant women; therefore, use during pregnancy only if the potential benefit justifies the potential risk to the fetus In some cases, the clinical picture is consistent with serotonin syndrome Effect on labor and delivery in humans is unknown Neonates exposed to escitalopram and other SSRIs/SNRIs Neonates exposed to SSRIs/SNRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding Such complications can arise immediately upon delivery Reported clinical findings include respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor,... Interaction: Increased risk of bleeding when used with aspirin, NSAIDs or drugs that affect coagulation. Serum levels may be reduced by CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (e.g. nafcillin, nevirapine). Serum levels may also be increased by CYP2C19 inhibitors (e.g. fluconazole, fluvoxamine, omeprazole) or CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin). May increase serum levels of desipramine or metoprolol. Increased risk of serotonin syndrome when used with linezolid or sibutramine. Escitalopram may enhance the sedative effects of alcohol. Potentially Fatal: Concomitant administration with MAOIs may lead to serious or fatal reactions; should not be started until at least 2...