Nebanol Plus - Ointment Bacitracin Zinc + Neomycin Sulphate + Polymixin B topical - 3.5mg+400IU+5000IU/gm 1 10gm tube(s) / 10gm tube Square Pharmaceuticals PLC. Introduction: Nebanol Plus is a combination medicine. It is used to treat various types of fungal skin infections. It minimizes symptoms of skin infection such as redness, swelling, itching, etc., by acting against the infection-causing microorganisms. Nebanol Plus is only meant for external use and should be used as advised by your doctor. A thin layer of the medicine should be applied only to the affected areas of the skin with clean and dry hands. Wash your hands before and after applying the medicine. If it gets into your eyes, nose, mouth, or vagina rinse with water. It may take several... Uses of Nebanol Plus: Bacterial skin infections Side effects of Nebanol Plus: Application site reactions (burning, irritation, itching and redness) How to use Nebanol Plus: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment. How Nebanol Plus works: Nebanol Plus is a combination of three antibiotics: Bacitracin, Neomycin and Polymyxin B. These antibiotics work by killing the bacteria or stopping their growth on the skin. Together, they treat your skin infection effectively. Indication: Minor cuts, Scrapes, Burns, Eczematoid dermatitis, Neurodermatitis, Eczema, Anogenital pruritus, Impetigo, Contact dermatitis, Bacterial skin infections. Adult Dose: Treatment/Prophylaxis Superficial Skin Infection Apply topically 3 times daily. Child Dose: Treatment/Prophylaxis Superficial Skin Infection Apply topically 3 times daily. Contraindication: Hypersensitivity Mode of Action: Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents. Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular... Precaution: Allergic cross-reactions may occur which could prevent the use of any or all of the following antibiotics for the treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin. Lactation: unknown if distributed in breast milk Side Effect: >10% Allergic contact dermatitis (60%) Pregnancy Category Note: Pregnancy Category: C Lactation: unknown if distributed in breast milk Interaction: Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents. Neomycin Sulphate: Additive nephrotoxic and neurotoxic effect w/ other aminoglycosides (e.g. paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). May impair the absorption of other drugs (e.g. phenoxymethylpenicillin, digoxin, methotrexate and some vit). May reduce the efficacy of OCs. May enhance the effect of acarbose. May enhance the effect of non-depolarising muscle relaxants. May antagonise the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in...