Naz - Eye Drop Fluconazole 0.3% Eye prep - 0.30% 1 5ml drop(s) / 5ml drop Reman Drug Laboratories Ltd. Introduction: Naz is an antifungal medication which treats eye infections. It works by killing the fungi in the eye by destroying their cell membrane. This relieves discomfort, itching and irritation in the eye. Naz is for external use only. Take it in the dose and duration as advised by your doctor. Wash your hands before and after applying the medicine. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. This medicine should be used regularly to get the most benefit from it. If you... Uses of Naz: Fungal infections of eye Side effects of Naz: Eye irritationStinging in the eyes How to use Naz: This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. How Naz works: Naz is an antifungal medication which treats eye infections. It works by killing the fungi in the eye by destroying their cell membrane. This relieves discomfort, itching and irritation in the eye. What if you forget to take Naz?: If you miss a dose of Naz, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Fungal corneal ulcers, Fungal keratitis, Fungal eye infections Adult Dose: Adult: 1 - 2 drops to be instilled into the affected eye 5 times daily. Contraindication: The drug is contraindicated in patients with hypersensitivity to azoles. Mode of Action: Fluconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., Trichophyton spp. Precaution: Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than C. albicans. Side Effect: This drug is generally well tolerated. Eosinophillia has been reported in some patients. Interaction: May increase plasma concentrations of oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), phenytoin, theophylline, tofacitinib, rifabutin. May increase prothrombin time w/ anticoagulants. May cause significant increase in ciclosporin levels in renal transplant patients w/ or w/o renal impairment. Rifampicin reduces fluconazole levels. May increase risk of nephrotoxicity w/ tacrolimus. May increase the effect of short-acting benzodiazepines (e.g. midazolam). Potentially Fatal: Increased risk of cardiac arrhythmias or QT prolongation w/ terfenadine, cisapride, astemizole, pimozide, quinidine, halofantrine and erythromycin.