Milk Of Magnesia(Acme's)114 ml - Suspension Magnesium Hydroxide - 400mg/5ml 1 114ml bot(s) / 114ml bot The ACME Laboratories Ltd. Indication: Heartburn, Constipation, Indigestion, Gastrointestinal hyperacidity, Osmotic laxative Adult Dose: Constipation Magnesium hydroxide (400 mg/5 mL): 30-60 mL/day PO at bedtime or in divided doses Acid Indigestion Magnesium hydroxide (400 mg/5 mL): 5-15 mL PO q4hr; no more than 4 doses per 24-hour period Child Dose: Constipation 12 years: 30-60 mL/day (400 mg/5 mL) Acid Indigestion Liquid 12 years: 5-15 mL (400 mg/5 mL) PO q4hr; no more than 4 doses per 24-hour period Contraindication: Intestinal obstruction, faecal impaction; renal failure; appendicitis. Mode of Action: Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride. Precaution: Colostomy, ileostomy; electrolyte imbalance. Monitor for toxicity in patients with impaired renal function. Pregnancy. Lactation: Use in nursing mothers appears to be safe Side Effect: Abdominal cramping, Diarrhea, Electrolyte imbalance, Hypotension, Muscle weakness, Respiratory depression, Hypermagnesaemia (in patients with renal impairment). Paralytic ileus. Interaction: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.