Microgest 200 - Capsule Progesterone - 200mg 10 Capsule(s) / Strip Renata Limited Introduction: Microgest 200 is a natural female sex hormone, progesterone. It is used to treat menstrual and pregnancy-related issues that are caused due to hormonal imbalance. It is also prescribed along with estrogen as a part of hormonal replacement therapy for preventing endometrial hyperplasia (thickening of the lining of the uterus). It should be taken with food. It should be taken at the same time each day to get the most benefit. You should continue taking it for as long as your doctor has told you to, even if you feel well. The most common side effects include headache, feeling very... Uses of Microgest 200: Hormone replacement therapyFemale infertility Side effects of Microgest 200: FatigueSleepinessHeadacheAbdominal pain How to use Microgest 200: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Microgest 200 is to be taken with food. How Microgest 200 works: Microgest 200 is a progesterone (female hormone). It helps to establish and maintain pregnancy. It also prevents the increase in thickness of the endometrium (lining of the uterus) caused by estrogen. Indication: Premenstrual syndrome, Contraception, Menopausal HRT, Amenorrhoea, Recurrent miscarriage Adult Dose: Oral Progestogen component of menopausal hormonal replacement therapy. Adult: 200 mg daily as a single daily dose at night for 12-14 days of each mth. Amenorrhoea Adult: 400 mg daily for 10 days. Dysfunctional uterine bleeding. Adult: 400 mg daily for 10 days. Prevention of Endometrial Hyperplasia. Adult: 200 mg PO at night for 12 days sequentially per 28-day cycle Vaginal Gel Dysfunctional uterine bleeding. Adult: 45 mg every other day from the 15th-25th day of the cycle. May increase dose to 90 mg in non-responders. Amenorrhoea. Adult: 45 mg every other day from the 15th-25th day of the cycle.... Contraindication: Hypersensitivity; thrombophloebitis; cerebral apoplexy; severe hepatic impairment; undiagnosed vag bleeding, incomplete abortion, hormone-dependent carcinoma, as a diagnostic test for pregnancy; pregnancy. History or current high risk of arterial disease. Mode of Action: Progesterone is the main hormone secreted by corpus luteum. It induces secretory changes in the endometrium, promotes mammary gland development, relaxes uterus, blocks follicular maturation and ovulation, and maintains pregnancy. Precaution: Family history of breast cancer and or DVT/PE, current/history of depression, endometriosis, DM, HTN, bone mineral density changes, renal/hepatic impairment, bone metabolic disease, SLE; conditions exacerbated by fluid retention (eg, migraine, asthma, epilepsy). Discontinue if the following develop jaundice, visual problems (may cause contact lens intolerance), any signs of VTE, migraine with unusual severity, significang blood pressure increase, severe depression, increased risk of thromboembolic complications after surgery. Discontinue 4 week before major surgery or prolonged immobilization. Patients on warfarin, oral anticoagulants (increase in anticoagulant dose may be warranted). Some studies link OCP use with increased risk of breast cancer, whereas... Side Effect: >10% Headache (10-31%),Breast tenderness (16-27%),Dizziness (15-24%),Abdominal pain (10-20%),Depression (19%),Breast pain (6-16%),Viral disease (7-12%) 1-10% Vaginal discharge (10%),Fatigue (8-9%),Nausea (8%),Mood swings (6%) Frequency Not Defined Dementia, probable(postmenopausal women >65 years of age, possible association),Anorexia,Weakness,Weight change (less common than with synthetic progestins),Vomiting,Edema,DVT (postmenopausal women 50-79 years of age),Thrombophlebitis,Myocardial infarction (postmenopausal women 50-79 years of age),Stroke (postmenopausal women 50-79 years of age),Pulmonary emboli (postmenopausal women 50-79 years of age),Amenorrhea (less common than with synthetic progestins),Breakthrough bleeding (less common than with synthetic progestins),Change in menstrual flow(less common than with synthetic progestins),Spotting (less common than with synthetic progestins),Breast changes (less common than with synthetic progestins),Invasive...